Opioids pp 307-346 | Cite as

Regulation of Opioid Peptide Gene Expression

  • V. Höllt
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 104 / 1)


Chromaffin Cell Opioid Peptide POMC mRNA Bovine Chromaffin Cell POMC Gene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. Affolter HU, Reisine T (1985) Corticotropin releasing factor increases proopiomelanocortin messenger RNA in mouse anterior pituitary tumor cells. J Biol Chem 260: 15477–15481PubMedGoogle Scholar
  2. Aloyo VJ, Lewis ME, Walker RF (1990) Opioid peptide mRNAs in the rat pineal gland. In: Quirion R, Jhamandas K, Giounalakis C (eds) The international narcotics research conference (IRNC)’89. Liss, New York, pp 235–238Google Scholar
  3. Angelogianni P, Gianoulakis C (1990) Ethanol regulation of proopiomelanocortin biosynthesis in the rat hypothalamus. In: Van Ree J, Molder AH, Wiegant VM, van Wimersma Greidanus TB (eds) New leads in opioid research. Elsevier, Amsterdam, pp 117–118Google Scholar
  4. Angulo JA, Christoph GR, Manning RW, Burkhart BA, Davis LG (1987) Reduction of dopamine receptor activity differentially alters striatal neuropeptide mRNA levels. Adv Exp Med Biol 221: 385–391PubMedGoogle Scholar
  5. Angulo JA, Cadet JL, McEwen BS (1990) Sigma receptor blockade by BMY 14802 affects enkephalinergic and tachykinin cells differentially in the striatum of the rat. Eur J Pharmacol 175: 225–228PubMedGoogle Scholar
  6. Antakly T, Sasaki A, Liotta AS, Palkovits M, Krieger DT (1985) Induced expression of the glucocorticoid receptor in the rat intermediate pituitary lobe. Science 229: 277–279PubMedGoogle Scholar
  7. Autelitano DJ, Blum M, Roberts JL (1989) Changes in rat pituitary nuclear and cytoplasmic pro-opiomelanocortin RNAs associated with adrenalectomy and glucocorticoid replacement. Mol Cell Endocrinol 66: 171–180PubMedGoogle Scholar
  8. Autelitano DJ, Blum M, Lopingco M, Allen RG, Roberts JL (1990) Corticotropin- releasing factor differentially regulates anterior and intermediate pituitary lobe proopiomelanocortin gene transcription, nuclear precursor RNA and mature mRNA in vivo. Neuroendocrinology 51: 123–130PubMedGoogle Scholar
  9. Beaulieu S, Gagne B, Barden N (1988) Glucocorticoid regulation of proopiomelanocortin messenger ribonucleic acid content of rat hypothalamus. Mol Endocrinol 2: 727–731PubMedGoogle Scholar
  10. Birnberg NC, Lissitzky JC, Hinman M, Herbert E (1983) Glucocorticoids regulate proopiomelanocortin gene expression in vivo at the levels of transcription and secretion. Proc Natl Acad Sci USA 80: 6982–6986PubMedGoogle Scholar
  11. Blanc D, Cupo A, Castanas E, Bourhim N, Giraud P, Bannon MJ, Eiden LE (1985) Influence of acute, subchronic and chronic treatment with neuroleptic (haloperidol) on enkephalins and their precursors in the striatum of rat brain. Neuropeptides 5: 567–570PubMedGoogle Scholar
  12. Bloch B, Le-Guellec D, de-Keyzer Y (1985) Detection of the messenger RNAs coding for the opioid peptide precursors in pituitary and adrenal by “in situ” hybridization: study in several mammal species. Neurosci Lett 53: 141–148PubMedGoogle Scholar
  13. Blum M, Roberts JL, Wardlaw SL (1989) Androgen regulation of proopiomelanocortin gene expression and peptide content in the basal hypothalamus. Endocrinology 124: 2283–2288PubMedGoogle Scholar
  14. Bommer M, Liebisch D, Kley N, Herz A, Noble E (1987) Histamine affects release and biosynthesis of opioid peptides primarily via H1-receptors in bovine chromaffin cells. J Neurochem 49: 1688–1696PubMedGoogle Scholar
  15. Boutillier AL, Sassone-Corsi P, Loeffler JP (1991) The protooncogene c-fos is induced by corticotropin-releasing factor and stimulates proopiomelanocortin gene transcription in pituitary cells. Mol Endocrinol 5: 1301–1310PubMedGoogle Scholar
  16. Bruhn TO, Sutton RE, Rivier CL, Vale WW (1984) Corticotropin-releasing factor regulates proopiomelanocortin messenger ribonucleic acid levels in vivo. Neuroendocrinology 39: 170–175PubMedGoogle Scholar
  17. Buckingham JC (1982) Secretion of corticotrophin and its hypothalamic releasing factor in response to morphine and opioid peptides. Neuroendocrinology 35: 111–116PubMedGoogle Scholar
  18. Byrd JC, Naranjo JR, Lindberg I (1987) Proenkephalin gene expression in the PC12 pheochromocytoma cell line: stimulation by sodium butyrate. Endocrinology 121: 1299–1305PubMedGoogle Scholar
  19. Chang AC, Israel A, Gazdar A, Cohen SN (1989) Initiation of pro-opiomelanocortin mRNA from a normally quiescent promoter in a human small cell lung cancer cell line. Gene 84: 115–126PubMedGoogle Scholar
  20. Charron J, Drouin J (1986) Glucocorticoid inhibition of transcription from episomal proopiomelanocortin gene promoter. Proc Natl Acad Sci USA 83: 8903–8907PubMedGoogle Scholar
  21. Chen CL, Madigan MB (1987) Regulation of testicular proopiomelanocortin gene expression. Endocrinology 121: 590–596PubMedGoogle Scholar
  22. Chen CL, Dionne FT, Roberts JL (1983) Regulation of the pro-opiomelanocortin mRNA levels in rat pituitary by dopaminergic compounds. Proc Natl Acad Sci USA 80: 2211–2215PubMedGoogle Scholar
  23. Chen CL, Chang CC, Krieger DT, Bardin CW (1986) Expression and regulation of proopiomelanocortin-like gene in the ovary and placenta: comparison with the testis. Endocrinology 118: 2382–2389PubMedGoogle Scholar
  24. Chowen-Breed J, Fraser HM, Vician L, Damassa DA, Clifton DK, Steiner RA (1989a) Testosterone regulation of proopiomelanocortin messenger ribonucleic acid in the arcuate nucleus of the male rat. Endocrinology 124: 1697–1702PubMedGoogle Scholar
  25. Chowen-Breed JA, Clifton DK, Steiner RA (1989b) Regional specificity of testosterone regulation of proopiomelanocortin gene expression in the arcuate nucleus of the male rat brain. Endocrinology 124: 2875–2881PubMedGoogle Scholar
  26. Chronwall BM, Hook GR, Millington WR (1988) Dopaminergic regulation of the biosynthetic activity of individual melanotropes in the rat pituitary intermediate lobe: a morphometric analysis by light and electron microscopy and in situ hybridization. Endocrinology 123: 1992–2002PubMedGoogle Scholar
  27. Civelli O, Douglass J, Goldstein A, Herbert E (1985) Sequence and expression of the rat prodynorphin gene. Proc Natl Acad Sci USA 82: 4291–4295PubMedGoogle Scholar
  28. Clark AJ, Lavender PM, Besser GM, Rees LH (1989) Pro-opiomelanocortin mRNA size heterogeneity in ACTH-dependent Cushing’s syndrome. J Mol Endocrinol 2: 3–9PubMedGoogle Scholar
  29. Clark AJ, Stewart MF, Lavender PM, Farrell W, Crosby SR, Rees LH, White A (1990) Defective glucocorticoid regulation of proopiomelanocortin gene expression and peptide secretion in a small cell lung cancer cell line. J Clin Endocrinol Metab 70: 485–490PubMedGoogle Scholar
  30. Comb M, Liston D, Martin M, Rosen H, Herbert E (1985) Expression of the human proenkephalin gene in mouse pituitary cells: accurate and efficient mRNA production and proteolytic processing. EMBO J 4: 3115–3122PubMedGoogle Scholar
  31. Comb M, Birnberg NC, Seasholtz A, Herbert E, Goodman HM (1986) A cyclic AMP- and phorbol esterinducible DNA element. Nature 323: 353–356PubMedGoogle Scholar
  32. Comb M, Mermod N, Hyman SE, Pearlberg J, Ross ME, Goodman HM (1988) Proteins bound at adjacent DNA elements act synergistically to regulate human proenkephalin cAMP inducible transcription. EMBO J 7: 3793–3805PubMedGoogle Scholar
  33. Cote TE, Felder R, Kebabian JW, Sekura RD, Reisine T, Affolter HU (1986) D-2 dopamine receptor-mediated inhibition of pro-opiomelanocortin synthesis in rat intermediate lobe. Abolition by pertussis toxin or activators of adenylate cyclase. J Biol Chem 261: 4555–4561Google Scholar
  34. Curran T, Rauscher FJ, Cohen DR, Franza BR Jr (1988) Beyond the second messenger: oncogenes and transcription factors. Cold Spring Harb Symp Quant Biol 53 (2): 769–777PubMedGoogle Scholar
  35. Dave JR, Eiden LE, Karanian JW, Eskay RL (1986) Ethanol exposure decreases pituitary corticotropin-releasing factor binding, adenylate cyclase activity, proopiomelanocortin biosynthesis, and plasma beta-endorphin levels in the rat. Endocrinology 118: 280–286PubMedGoogle Scholar
  36. Dave JR, Eiden LE, Lozovsky D, Waschek JA, Eskay RL (1987) Calcium- independent and calcium-dependent mechanisms regulate corticotropin- releasing factor-stimulated proopiomelanocortin peptide secretion and messenger ribonucleic acid production. Endocrinology 120: 305–310PubMedGoogle Scholar
  37. Day R, Schäfer MK-H, Watson SJ, Akil H (1990) Effects of hypophysectomy on dynorphin mRNA and peptide content in the rat adrenal gland. In: Quirion R, Jhamandas K, Giounalakis C (eds) The international narcotics conference (IRNC)’89. Liss, New York, pp 207–210Google Scholar
  38. De Keyzer Y, Bertagna X, Lenne F, Girard F, Luton JP, Kahn A (1985) Altered proopiomelanocortin gene expression in adrenocorticotropin-producing nonpituitary tumors. Comparative studies with corticotropic adenomas and normal pituitaries. J Clin Invest 76: 1892–1898Google Scholar
  39. De Keyzer Y, Bertagna X, Luton JP, Kahn A (1989) Variable modes of proopiomelanocortin gene transcription in human tumors. Mol Endocrinol 3: 215–223PubMedGoogle Scholar
  40. DeBold CR, Nicholson WE, Orth DN (1988a) Immunoreactive proopiomelanocortin ( POMC) peptides and POMC-like messenger ribonucleic acid are present in many rat nonpituitary tissues. Endocrinology 122: 2648–2657Google Scholar
  41. DeBold CR, Menefee JK, Nicholson WE, Orth DN (1988b) Proopiomelanocortin gene is expressed in many normal human tissues and in tumors not associated with ectopic adrenocorticotropin syndrome. Mol Endocrinol 2: 862–870PubMedGoogle Scholar
  42. DeBold CR, Mufson EE, Menefee JK, Orth DN (1988c) Proopiomelanocortin gene expression in a pheochromocytoma using upstream transcription initiation sites. Biochem Biophys Res Commun 155: 895–900PubMedGoogle Scholar
  43. Douglass J, Cox B, Quinn B, Civelli O, Herbert E (1987) Expression of the prodynorphin gene in male and female mammalian reproductive tissues. Endocrinology 120: 707–713PubMedGoogle Scholar
  44. Douglass J, McMurray CT, Garrett JE, Adelman JP, Calavetta L (1989) Characterization of the rat prodynorphin gene. Mol Endocrinol 3: 2070–2078PubMedGoogle Scholar
  45. Draisci G, Iadarola MJ (1989) Temporal analysis of increases in c-fos, preprodynorphin and preproenkephalin mRNAs in rat spinal cord. Brain Res Mol Brain Res 6: 31–37PubMedGoogle Scholar
  46. Drouin J, Chamberland M, Charron J, Jeannotte L, Nemer M (1985) Structure of the rat pro-opiomelanocortin ( POMC) gene. FEBS Lett 193: 54–58Google Scholar
  47. Drouin J, Trifiro MA, Plante RK, Nemer M, Erikson P, Wrange Y (1989) Glucocorticoid receptor binding to a specific DNA sequence is required for hormone-dependent repression of pro-opiomelanocortin gene transcription. Mol Cell Biol 9: 5305–5314PubMedGoogle Scholar
  48. Eberwine JH, Roberts JL (1984) Glucocorticoid regulation of pro-opiomelanocortin gene transcription in the rat pituitary. J Biol Chem 259: 2166–2170PubMedGoogle Scholar
  49. Eberwine JH, Jonassen JA, Evinger MJ, Roberts JL (1987) Complex transcriptional regulation by glucocorticoids and corticotropin-releasing hormone of proopiomelanocortin gene expression in rat pituitary cultures. DNA 6: 483–492PubMedGoogle Scholar
  50. Eiden LE, Giraud P, Dave JR, Hotchkiss AJ, Affolter HU (1984a) Nicotinic receptor stimulation activates enkephalin release and biosynthesis in adrenal chromaffin cells. Nature 312: 661–663PubMedGoogle Scholar
  51. Eiden LE, Giraud P, Affolter HU, Herbert E, Hotchkiss AJ (1984b) Alternative modes of enkephalin biosynthesis regulation by reserpine and cyclic AMP in cultured chromaffin cells. Proc Natl Acad Sci USA 81: 3949–3953PubMedGoogle Scholar
  52. Elkabes S, Loh YP (1988) Effect of salt loading on proopiomelanocortin (POMC) messenger ribonucleic acid levels, POMC biosynthesis, and secretion of POMC products in the mouse pituitary gland. Endocrinology 123: 1754–1760Google Scholar
  53. Farin C-J, Höllt V, Kley N (1990a) Proenkephalin gene expression in cultured chromaffin cells is regulated at the transcriptional level. In: Quirion R, Jhamandas K, Giounalakis C (eds) The international narcotics research conference (IRNC)’89. Liss, New York, pp 239–242Google Scholar
  54. Farin CJ, Kley N, Höllt V (1990b) Mechanisms involved in the transcriptional activation of proenkephalin gene expression in bovine chromaffin cells. J Biol Chem 265: 19116–19121PubMedGoogle Scholar
  55. Fischer-Colbrie R, Iacangelo A, Eiden LE (1988) Neural and humoral factors separately regulate neuropeptide Y, enkephalin, and chromogranin A and B mRNA levels in rat adrenal medulla. Proc Natl Acad Sci USA 85: 3240–3244PubMedGoogle Scholar
  56. Folkesson R, Monstein HJ, Geijer T, Pahlman S, Nilsson K, Terenius L (1988) Expression of the proenkephalin gene in human neuroblastoma cell lines. Brain Res 427: 147–154PubMedGoogle Scholar
  57. Folkesson R, Monstein HJ, Geijer T, Terenius L (1989) Modulation of proenkephalin A gene expression by cyclic AMP. Brain Res Mol Brain Res 5: 211–217PubMedGoogle Scholar
  58. Fremeau RT Jr, Lundblad JR, Pritchett DB, Wilcox JN, Roberts JL (1986) Regulation of pro-opiomelanocortin gene transcription in individual cell nuclei. Science 234: 1265–1269PubMedGoogle Scholar
  59. Gagner JP, Drouin J (1985) Opposite regulation of pro-opiomelanocortin gene transcription by glucocorticoids and CRH. Mol Cell Endocrinol 40: 25–32PubMedGoogle Scholar
  60. Gall C, Brecha N, Karten HJ, Chang KJ (1981) Localization of enkephalin-like immunoreactivity to identified axonal and neuronal populations of the rat hippocampus. J Comp Neurol 198: 335–350PubMedGoogle Scholar
  61. Garrett JE, Douglass JO (1989) Human chorionic gonadotropin regulates expression of the proenkephalin gene in adult rat Leydig cells. Mol Endocrinol 3: 2093–2100PubMedGoogle Scholar
  62. Garrett JE, Collard MW, Douglass JO (1989) Translational control of germ cell- expressed mRNA imposed by alternative splicing: opioid peptide gene expression in rat testis. Mol Cell Biol 9: 4381–4389PubMedGoogle Scholar
  63. Gee CE, Chen CL, Roberts JL, Thompson R, Watson SJ (1983) Identification of proopiomelanocortin neurones in rat hypothalamus by in situ cDNA-mRNA hybridization. Nature 306: 374–376PubMedGoogle Scholar
  64. Giraud P, Kowalski C, Barthel F, Becquet D, Renard M, Grino M, Boudouresque S, Loeffler JP (1991) Striatol proenkephalin turnover and gene transcription are regulated by cyclic AMP and protein kinase C-related pathways. Neuroscience 43: 67–79PubMedGoogle Scholar
  65. Gizang-Ginsberg E, Wolgemuth DJ (1985) Localization of mRNAs in mouse testes by in situ hybridization: distribution of alpha-tubulin and developmental stage specificity of pro-opiomelanocortin transcripts. Dev Biol 111: 293–305PubMedGoogle Scholar
  66. Graybiel AM (1986) Neuropeptides in the basal ganglia. Res Publ Assoc Res Nerv Ment Dis 64: 135–161PubMedGoogle Scholar
  67. Harbuz MS, Lightman SL (1989) Responses of hypothalamic and pituitary mRNA to physical and psychological stress in the rat. J Endocrinol 122: 705–711PubMedGoogle Scholar
  68. Harlan RE, Shivers BD, Romano GJ, Howells RD, Pfaff DW (1987) Localization of preproenkephalin in the rat brain and spinal cord by in situ hybridization. J Comp Neurol 258: 159–184PubMedGoogle Scholar
  69. Hatfield JM, Daikh DI, Adelman JP, Douglass J, Bond CT, Allen RG (1989) In situ hybridization detection of marked differences in pre-proopiomelanocortin messenger ribonucleic acid content of individual corticotropes and melanotropes. Endocrinology 124: 1359–1364PubMedGoogle Scholar
  70. Henricksen SJ, Chouvet G, Bloom FE (1982) In vivo cellular responses to electrophoretically applied dynorphin in the rat hippocampus. Life Sci 31: 1785–1788Google Scholar
  71. Höllt V, Haarmann I (1984) Corticotropin-releasing factor differentially regulates proopiomelanocortin messenger ribonucleic acid levels in anterior as compared to intermediate pituitary lobes of rats. Biochem Biophys Res Commun 124: 407–415PubMedGoogle Scholar
  72. Höllt V, Haarmann I (1985) Differential alterations by chronic treatment with morphine of pro-opiomelanocortin mRNA levels in anterior as compared to intermediate pituitary lobes of rats. Neuropeptides 5:481–484PubMedGoogle Scholar
  73. Höllt V, Horn G (1989) Nicotine and opioid peptides. In: Nordberg A, Fuxe K, Holmstedt B, Sundwall A (eds) Nicotinic receptors in the CNS: their role in synaptic transmission. Prog Brain Res 79: 187–193Google Scholar
  74. Höllt V, Horn G (1992) Effect of nicotine on mRNA levels encoding opioid peptides, vasopressin and α3 nicotinic receptor submit in the rat. Clin Investig 70: 224–231PubMedGoogle Scholar
  75. Höllt V, Sincini E (1988) Bombesin and structurally related peptides increase inositol-1-phosphate production in a corticotrophic cell line of the pituitary (AtT-20). Acta Endocrinol (Copenh) 117 [Suppl 287]: 206–206Google Scholar
  76. Höllt V, Haarmann I, Seizinger BR, Herz A (1982) Chronic haloperidol treatment increases the level of in vitro translatable messenger ribonucleic acid coding for the beta-endorphin/adrenocorticotropin precursor proopiomelanocortin in the pars intermedia of the rat pituitary. Endocrinology 110: 1885–1891PubMedGoogle Scholar
  77. Höllt V, Przewlocki R, Haarmann I, Almeida OF, Kley N, Millan MJ, Herz A (1986) Stress-induced alterations in the levels of messenger RNA coding for proopiomelanocortin and prolactin in rat pituitary. Neuroendocrinology 43: 277–282PubMedGoogle Scholar
  78. Höllt V, Haarmann I, Millan MJ, Herz A (1987) Prodynorphin gene expression is enhanced in the spinal cord of chronic arthritic rats. Neurosci Lett 73: 90–94PubMedGoogle Scholar
  79. Höllt V, Haarmann I, Reimer S (1989a) Opioid peptide gene expression in rats after chronic morphine treatment. Adv Biosci 75: 711–714Google Scholar
  80. Höllt V, Haarmann I, Reimer S (1989b) Opioid gene expression in rats after chronic morphine treatment. Adv Biosci 75: 711–714Google Scholar
  81. Horikawa S, Takai T, Toyosato M, Takahashi H, Noda M, Kakidani H, Kubo T, Hirose T, Inayama S, Hayashida H, Miyata T, Numa S (1983) Isolation and structural organization of the human preproenkephalin B gene. Nature 306: 611–614PubMedGoogle Scholar
  82. Howells RD, Kilpatrick DL, Bailey LC, Noe M, Udenfriend S (1986) Proenkephalin mRNA in rat heart. Proc Natl Acad Sci USA 83: 1960–1963PubMedGoogle Scholar
  83. Hunt SP, Pini A, Evan G (1987) Induction of c-fos-like protein in spinal cord neurons following sensory stimulation. Nature 328: 632–634PubMedGoogle Scholar
  84. Hyman SE, Comb M, Lin YS, Pearlberg J, Green MR, Goodman HM (1988) A common trans-acting factor is involved in transcriptional regulation of neurotransmitter genes by cyclic AMP. Mol Cell Biol 8: 4225–4233PubMedGoogle Scholar
  85. Hyman SE, Comb M, Pearlberg J, Goodman HM (1989) An AP-2 element acts synergistically with the cyclic AMP- and phorbol ester-inducible enhancer of the human proenkephalin gene. Mol Cell Biol 9: 321–324PubMedGoogle Scholar
  86. Iadarola MJ, Douglass J, Civelli O, Naranjo JR (1986) Increased spinal cord dynorphin mRNA during peripheral inflammation. Natl Inst Drug Abuse Res Monogr Ser 75: 406–409Google Scholar
  87. Iadarola MJ, Brady LS, Draisci G, Dubner R (1988a) Enhancement of dynorphin gene expression in spinal cord following experimental inflammation: stimulus specificity, behavioral parameters and opioid receptor binding. Pain 35: 313–326PubMedGoogle Scholar
  88. Iadarola MJ, Douglass J, Civelli O, Naranjo JR (1988b) Differential activation of spinal cord dynorphin and enkephalin neurons during hyperalgesia: evidence using cDNA hybridization. Brain Res 455: 205–212PubMedGoogle Scholar
  89. Inturrisi CE, Branch AD, Robertson HD, Howells RD, Franklin SO, Shapiro JR, Calvano SE, Yoburn BC (1988a) Glucocorticoid regulation of enkephalins in cultured rat adrenal medulla. Mol Endocrinol 2: 633–640PubMedGoogle Scholar
  90. Inturrisi CE, LaGamma EF, Franklin SO, Huang T, Nip TJ, Yoburn BC (1988b) Characterization of enkephalins in rat adrenal medullary explants. Brain Res 448: 230–236PubMedGoogle Scholar
  91. Israel A, Cohen SN (1985) Hormonally mediated negative regulation of human pro-opiomelanocortin gene expression after transfection into mouse L cells. Mol Cell Biol 5: 2443–2453PubMedGoogle Scholar
  92. Jeannotte L, Burbach JPH, Drouin J (1987a) Unusual proopiomelanocortin ribonucleic acids in extrapituitary tissues: intronless transcripts in testes and long poly ( A) tails in the hypothalamus. Mol Endocrinol 1: 749–757Google Scholar
  93. Jeannotte L, Trifiro MA, Plante RK, Chamberland M, Drouin J (1987b) Tissue- specific activity of the pro-opiomelanocortin gene promoter. Mol Cell Biol 7: 4058–4064PubMedGoogle Scholar
  94. Jin DF, Muffly KE, Okulicz WC, Kilpatrick DL (1988) Estrous cycle- and pregnancy-related differences in expression of the proenkephalin and pro-opiomelanocortin genes in the ovary and uterus. Endocrinology 122: 1466–1471PubMedGoogle Scholar
  95. Jingami H, Nakanishi S, Imura H, Numa S (1984) Tissue distribution of messenger RNAs coding for opioid peptide precursors and related RNA. Eur J Biochem 142: 441–447PubMedGoogle Scholar
  96. Kanamatsu T, Unsworth CD, Diliberto EJ Jr, Viveros OH, Hong JS (1986) Reflex splanchnic nerve stimulation increases levels of proenkephalin A mRNA and proenkephalin A-related peptides in the rat adrenal medulla. Proc Natl Acad Sci USA 83: 9245–9249PubMedGoogle Scholar
  97. Keshet E, Polakiewicz RD, Itin A, Ornoy A, Rosen H (1989) Proenkephalin A is expressed in mesodermal lineages during organogenesis. EMBO J 8: 2917–2923PubMedGoogle Scholar
  98. Kessler U, Sincini E, Stalla GK, Höllt V (1989) Bombesin stimulates release of β-endorphin in corticotrophic pituitary cells in vitro. Acta Endocrinol (Copenh) 120 [Suppl 1]: 206–206Google Scholar
  99. Kilpatrick DL, Millette CF (1986) Expression of proenkephalin messenger RNA by mouse spermatogenic cells. Proc Natl Acad Sci USA 83: 5015–5018PubMedGoogle Scholar
  100. Kilpatrick DL, Rosenthal JL (1986) The proenkephalin gene is widely expressed within the male and female reproductive systems of the rat and hamster. Endocrinology 119: 370–374PubMedGoogle Scholar
  101. Kilpatrick DL, Howells RD, Fleminger G, Udenfriend S (1984) Denervation of rat adrenal glands markedly increases preproenkephalin mRNA. Proc Natl Acad Sci USA 81: 7221–7223PubMedGoogle Scholar
  102. Kilpatrick DL, Howells RD, Noe M, Bailey LC, Udenfriend S (1985) Expression of preproenkephalin-like mRNA and its peptide products in mammalian testis and ovary. Proc Natl Acad Sci USA 82: 7467–7469PubMedGoogle Scholar
  103. Kilpatrick DL, Borland K, Jin DF (1987) Differential expression of opioid peptide genes by testicular germ cells and somatic cells. Proc Natl Acad Sci USA 84: 5695–5699PubMedGoogle Scholar
  104. Kley N (1988) Multiple regulation of proenkephalin gene expression by protein kinase C. J Biol Chem 263: 2003–2008PubMedGoogle Scholar
  105. Kley N, Loeffler JP, Pittius CW, Höllt V (1986) Proenkephalin A gene expression in bovine adrenal chromaffin cells is regulated by changes in electrical activity. EMBO J 5: 967–970PubMedGoogle Scholar
  106. Kley N, Loeffler JP, Pittius CW, Höllt V (1987a) Involvement of ion channels in the induction of proenkephalin A gene expression by nicotine and cAMP in bovine chromaffin cells. J Biol Chem 262: 4083–4089PubMedGoogle Scholar
  107. Kley N, Loeffler JP, Höllt V (1987b) Ca2+-dependent histaminergic regulation of proenkephalin mRNA levels in cultured adrenal chromaffin cells. Neuroendocrinology 46: 89–92PubMedGoogle Scholar
  108. Knight RM, Farah JM, Bishop JF, O’Donohue TL (1987) CRF and cAMP regulation of POMC gene expression in corticotrophic tumor cells. Peptides 8: 927–934PubMedGoogle Scholar
  109. Kobierski LA, Chu H-M, Comb MJ (1991) cAMP-dependent regulation of proenkephalin by JunD and JunB: Positive and negative effects of AP-1 proteins. Proc Natl Acad Sci 88:10222–10226Google Scholar
  110. Korner M, Rattner A, Manxion F, Sen T, Citri Y (1989) A brain-specific transcription activator. Neuron 3: 563–572PubMedGoogle Scholar
  111. Kowalski C, Giraud P, Boudouresque F, Lissitzky JC, Cupo A, Renard M, Saura RM, Oliver C (1989) Enkephalins expression in striatal cell cultures. Adv Biosci 75: 225–228Google Scholar
  112. Kraus J, Höllt V (1990) A negative regulatory element in the upstream promoter region of the human proopiomelanocortin gene. In: Van Ree J, Mulder AJ, Wiegant VM, van Wimersma Greidanus TB (eds) New leads in opioid research. Elsevier, Amsterdam, pp 115–117Google Scholar
  113. Kraus J, Buchfelder M, Höllt V (1992) Regulatory elements of the human proopiomelanocortin gene promoter. DNA Cell Biol (in press)Google Scholar
  114. Lacaze-Masmonteil T, de-Keyzer Y, Luton JP, Kahn A, Bertagna X (1987) Characterization of proopiomelanocortin transcripts in human nonpituitary tissures. Proc Natl Acad Sci USA 84: 7261–7265PubMedGoogle Scholar
  115. LaGamma EF, Adler JE (1987) Glucocorticoids regulate adrenal opiate peptides. Mol Brain Res 2: 125–130Google Scholar
  116. LaGamma EF, White JD, Adler JE, Krause JE, McKelvy JF, Black IB (1985) Depolarization regulates adrenal preproenkephalin mRNA. Proc Natl Acad Sci USA 82: 8252–8255PubMedGoogle Scholar
  117. LaGamma EF, White JD, McKelvy JF, Black IB (1988) Second messenger mechanisms governing opiate peptide transmitter regulation in the rat adrenal medulla. Brain Res 441: 292–298Google Scholar
  118. LaGamma EF, Goldstein NK, Snyder Jr SB, Weisinger G (1989) Prerproenkephalin DNA-binding proteins in the rat: 5’-flanking region. Mol Brain Res 5: 131–140Google Scholar
  119. Le Moine C, Normand E, Guitteny AF, Fouque B, Teoule R, Bloch B (1990) Dopamine receptor gene expression by enkephalin neurons in rat forebrain. Proc Natl Acad Sci USA 87: 230–234PubMedGoogle Scholar
  120. Lee PHK, Zhao D, Xie CW, McGinty JF, Mitchell CL, Hong JS (1989) Changes of proenkephalin and prodynorphin mRNAs and related peptides in rat brain during the development of deep prepyriform cortex kindling. Mol Brain Res 6: 263–273PubMedGoogle Scholar
  121. Leviel V, Fayada C, Guibert B, Chaminade M, Machek G, Mallet J, Biguet NF (1990) Short- and long-term alterations of gene expression in limbic structures by repeated electroconvulsive-induced seizures. J Neurochem 54: 899–904PubMedGoogle Scholar
  122. Levin N, Blum M, Roberts JL (1989) Modulation of basal and corticotropin- releasing factor-stimulated proopiomelanocortin gene expression by vasopressin in rat anterior pituitary. Endocrinology 125: 2957–2966PubMedGoogle Scholar
  123. Levy A, Lightman SL (1988) Quantitative in-situ hybridization histochemistry in the rat pituitary gland: effect of bromocriptine on prolactin and pro-opiomelanocortin gene expression. J Endocrinol 118: 205–210PubMedGoogle Scholar
  124. Li H, Risbridger GP, Funder JW, Clements JA (1989) Effect of ethane dimethane sulphonate on proopiomelanocortin ( POMC) mRNA and POMC-derived peptides in the rat testis. Mol Cell Endocrinol 65: 203–207Google Scholar
  125. Li SJ, Sivam SP, McGinty JF, Jiang HK, Douglass J, Calavetta L, Hong JS (1988) Regulation of the metabolism of striatal dynorphin by the dopaminergic system. J Pharmacol Exp Ther 246: 403–408PubMedGoogle Scholar
  126. Lightman SL, Young WS (1987a) Changes in hypothalamic preproenkephalin A mRNA following stress and opiate withdrawal. Nature 328: 643–645PubMedGoogle Scholar
  127. Lightman SL, Young WS (1987b) Vasopressin, oxytocin, dynorphin, enkephalin and corticotrophin-releasing factor mRNA stimulation in the rat. J Physiol (Lond) 394: 23–39Google Scholar
  128. Lightman SL, Young WS (1988) Corticotrophin-releasing factor, vasopressin and pro-opiomelanocortin mRNA responses to stress and opiates in the rat. J Physiol (Lond) 403: 511–523Google Scholar
  129. Llorens-Cortes C, Giros B, Quach T, Schwartz J-C (1990) Adaptive changes in two indices of enkephalin neuron activity in mouse striatum following gabaergic stimulation. In: Quirion R, Jhanmandas K, Gianoulakis C (eds) The international narcotics research conference (INRC)’89. Liss, New York, pp 203– 206Google Scholar
  130. Loeffler JP, Kley N, Pittius CW, Höllt V (1985) Corticotropin-releasing factor and forskolin increase proopiomelanocortin messenger RNA levels in rat anterior and intermediate cells in vitro. Neurosci Lett 62: 383–387PubMedGoogle Scholar
  131. Loeffler JP, Kley N, Pittius CW, Höllt V (1986a) Calcium ion and cyclic adenosine 3’,5’-monophosphate regulate proopiomelanocortin messenger ribonucleic acid levels in rat intermediate and anterior pituitary lobes. Endocrinology 119: 2840–2847PubMedGoogle Scholar
  132. Loeffler JP, Demeneix BA, Pittius CW, Kley N, Haegele KD, Höllt V (1986b) GABA differentially regulates the gene expression of proopiomelanocortin in rat intermediate and anterior pituitary. Peptides 7: 253–258PubMedGoogle Scholar
  133. Loeffler JP, Kley N, Pittius CW, Höllt V (1986c) Regulation of proopiomelanocortin ( POMC) mRNA levels in primary pituitary cultures. Natl Inst Drug Abuse Res Monogr Ser 75: 397–400Google Scholar
  134. Loeffler JP, Demeneix BA, Kley NA, Höllt V (1988) Dopamine inhibition of proopiomelanocortin gene expression in the intermediate lobe of the pituitary. Interactions with corticotropin-releasing factor and the beta-adrenergic receptors and the adenylate cyclase system. Neuroendocrinology 47: 95–101Google Scholar
  135. Loeffler JP, Kley N, Louis JC, Demeneix BA (1989) Ca2+ regulates hormone secretion and proopiomelanocortin gene expression in melanotrope cells via the calmodulin and the protein kinase C pathways. J Neurochem 52: 1279–1283PubMedGoogle Scholar
  136. Low KG, Nielsen CP, West NB, Douglass J, Brenner RM, Maslar IA, Melner MH (1989) Proenkephalin gene expression in the primate uterus: regulation by estradiol in the endometrium. Mol Endocrinol 3: 852–857PubMedGoogle Scholar
  137. Luini A, Lewis D, Guild S, Corda D, Axelrod J (1985) Hormone secretagogues increase cytosolic calcium by increasing cAMP in corticotropin-secreting cells. Proc Natl Acad Sci USA 82: 8034–8038PubMedGoogle Scholar
  138. Lundblad JR, Roberts JL (1988) Regulation of proopiomelanocortin gene expression in pituitary. Endocr Rev 9: 135–158PubMedGoogle Scholar
  139. McGinty JF, Henriksen SJ, Goldstein A, Terenius L, Bloom FE (1983) Dynorphin is contained within hippocampal mossy fibers: immunochemical alterations after kainic acid administration and colchicine-induced neurotoxicity. Proc Natl Acad Sci USA 80: 589–593PubMedGoogle Scholar
  140. McLoughlin L, Buzzetti R, Lavender PM, Clark A, Rees LH (1990) Pro-opiomelanocortin derived peptides in cells of the human immune system. In: Van Ree J, Mulder AH, Wiegant VM, van Wimersma Greidanus TB (eds) New leads in opioid research. Elsevier, Amsterdam, pp 373–374Google Scholar
  141. McMurray CT, Devi L, Calavetta L, Douglass JO (1989) Regulated expression of the prodynorphin gene in the R2C Leydig tumor cell line. Endocrinology 124: 49–59PubMedGoogle Scholar
  142. Melner MH, Young SL, Czerwiec FS, Lyn D, Puett D, Roberts JL, Koos RD (1986) The regulation of granulosa cell proopiomelanocortin messenger ribonucleic acid by androgens and gonadotropins. Endocrinology 119: 2082–2088PubMedGoogle Scholar
  143. Mishina M, Kurosaki T, Yamamoto T, Notake M, Masu M, Numa S (1982) DNA sequences required for transcription in vivo of the human corticotropin-beta-lipotropin precursor gene. EMBO J 1: 1533–1538PubMedGoogle Scholar
  144. Mocchetti A, Ritter A, Costa E (1989) Down-regulation of proopiomelanocortin synthesis and beta-endorphin utilization in hypothalamus of morphine-tolerant rats. J Mol Neurosci 1: 33–38PubMedGoogle Scholar
  145. Mocchetti I, Giorgi O, Schwartz JP, Costa E (1984) A reduction of the tone of 5-hydroxytryptamine neurons decreases utilization rates of striatal and hypothalamic enkephalins. Eur J Pharmacol 106: 427–430PubMedGoogle Scholar
  146. Mocchetti I, Guidotti A, Schwartz JP, Costa E (1985) Reserpine changes the dynamic state of enkephalin stores in rat striatum and adrenal medulla by different mechanisms. J Neurosci 5: 3379–3385PubMedGoogle Scholar
  147. Mocchetti I, Naranjo JR, Costa E (1987) Regulation of striatal enkephalin turnover in rats receiving antagonists of specific dopamine receptor subtypes. J Pharmacol Exp Ther 241: 1120–1124PubMedGoogle Scholar
  148. Moneta ME, Höllt V (1990) Perforant path kindling induces differential alterations in the mRNA levels coding for prodynorphin and proenkephalin in the rat hippocampus. Neurosci Lett 110: 273–278PubMedGoogle Scholar
  149. Monstein HJ, Geijer T (1988) A highly sensitive Northern blot assay detects multiple proenkephalin A-like mRNAs in human caudate nucleus and pheochromocytoma. Biosci Rep 8: 255–261PubMedGoogle Scholar
  150. Monstein HJ, Folkesson R, Terenius L (1986) Proenkephalin A-like mRNA in human leukemia leukocytes and CNS-tissues. Life Sci 39: 2237–2241PubMedGoogle Scholar
  151. Morris B, Herz A, Höllt V (1989) Location of striatal opioid gene expression, and its modulation by the mesostriatal dopamine pathway: an in situ hybridization study. J Mol Neurosci 1: 9–18PubMedGoogle Scholar
  152. Morris BJ, Haarmann I, Kempter B, Höllt V, Herz A (1986) Localization of prodynorphin messenger RNA in rat brain by in situ hybridization using a synthetic oligonucleotide probe. Neurosci Lett 69: 104–108PubMedGoogle Scholar
  153. Morris BJ, Moneta ME, ten-Bruggencate G, Höllt V (1987) Levels of prodynorphin mRNA in rat dentate gyrus are decreased during hippocampal kindling. Neurosci Lett 80: 298–302PubMedGoogle Scholar
  154. Morris BJ, Feasey KJ, ten-Bruggencate G, Herz A, Höllt V (1988a) Electrical stimulation in vivo increases the expression of proenkephalin mRNA and decreases the expression of prodynorphin mRNA in rat hippocampal granule cells. Proc Natl Acad Sci USA 85: 3226–3230PubMedGoogle Scholar
  155. Morris BJ, Reimer S, Höllt V, Herz A (1988b) Regulation of striatal prodynorphin mRNA levels by the raphe-striatal pathway. Brain Res 464: 15–22PubMedGoogle Scholar
  156. Morris BJ, Höllt V, Herz A (1988c) Opioid gene expression in rat striatum is modulated via opioid receptors: evidence from localized receptor inactivation. Neurosci Lett 89: 80–84PubMedGoogle Scholar
  157. Morris BJ, Höllt V, Herz A (1988d) Dopaminergic regulation of striatal proenkephalin mRNA and prodynorphin mR. Neuroscience 25: 525–532PubMedGoogle Scholar
  158. Nakai Y, Usui T, Tsukuda T, Takahashi H, Fukata U, Fukushima M, Senoo K, Imura H (1991) Molecular mechanisms of glucocorticoid inhibition of human proopiomelanocortin gene transcription. J Steroid Biochem Molec Biol 40: 301–306PubMedGoogle Scholar
  159. Nakamura M, Nakanishi S, Sueoka S, Ipura H, Numa S (1978) Effects of steroid hormones on the level of corticotropin messenger RNA activity in cultured mouse-pituitary-tumor cells. Eur J Biochem 86:61–66 Nakanishi S, Inoue A, Kita T, Nakamura M, Chang AC, Cohen SN, Numa S (1979) Nucleotide sequence of cloned cDNA for bovine corticotropin-beta-lipotropin precursor. Nature 278: 423–427Google Scholar
  160. Nakanishi S, Teranishi Y, Watanabe Y, Notake M, Noda M, Kakidani H, Jingami H, Numa S (1981) Isolation and characterization of the bovine corticotropin/beta-lipotropin precursor gene. Eur J Biochem 115: 429–438PubMedGoogle Scholar
  161. Naranjo JR, Iadarola MJ, Costa E (1986a) Changes in the dynamic state of brain proenkephalin-derived peptides during amygdaloid kindling. J Neurosci Res 16: 75–87PubMedGoogle Scholar
  162. Naranjo JR, Mocchetti I, Schwartz JP, Costa E (1986b) Permissive effect of dexamethasone on the increase of proenkephalin mRNA induced by depolarization of chromaffin cells. Proc Natl Acad Sci USA 83: 1513–1517PubMedGoogle Scholar
  163. Naranjo JR, Wise BC, Mellstrom B, Costa E (1988) Negative feedback regulation of the content of proenkephalin mRNA in chromaffin cell cultures. Neuropharmacology 27: 337–343PubMedGoogle Scholar
  164. Naranjo JR, Mellström B, Achaval M, Sassone-Corsi P (1991) Molecular pathways of pain: fos/jun-mediated activation of a noncanonical AP-1 site in the prodynorphin gene. Neuron 6: 606–617Google Scholar
  165. Nishimori T, Moskowitz MA, Uhl GR (1988) Opioid peptide gene expression in rat trigeminal nucleus caudalis neurons: normal distribution and effects of trigeminal deafferentation. J Comp Neurol 274: 142–150PubMedGoogle Scholar
  166. Nishimori T, Buzzi MG, Moskowitz MA, Uhl GR (1989) Proenkephalin mRNA expression in nucleus caudalis neurons is enhanced by trigeminal stimulation. Mol Brain Res 6: 203–210PubMedGoogle Scholar
  167. Noble EP, Bommer M, Sincini E, Costa T, Herz A (1986) Hl-histaminergic activation stimulates inositol-1-phosphate accumulation in chromaffin cells. Biochem Biophys Res Commun 135: 566–573PubMedGoogle Scholar
  168. Noda M, Teranishi Y, Takahashi H, Toyosato M, Notake M, Nakanishi S, Numa S (1982) Isolation and structural organization of the human preproenkephalin gene. Nature 297: 431–434PubMedGoogle Scholar
  169. Noguchi K, Kowalski K, Traub R, Solodkin A, Iadarola MJ, Ruda MA (1991) Dynorphin expression and fos-like immunoreactivity following inflammation- induced hyperalgesia are colocalized in spinal cord neurones. Mol Brain Res 10: 227–233PubMedGoogle Scholar
  170. Normand E, Popovici T, Onteniente B, Fellmann D, Piatier-Tonneau D, Auffray C, Bloch B (1988) Dopaminergic neurons of the substantia nigra modulate preproenkephalin A gene expression in rat striatal neurons. Brain Res 439: 39–46PubMedGoogle Scholar
  171. Notake M, Tobimatsu T, Watanabe Y, Takahashi H, Mishina M, Numa S (1983a) Isolation and characterization of the mouse corticotropin-beta-lipotropin precursor gene and a related pseudogene. FEBS Lett 156: 67–71PubMedGoogle Scholar
  172. Notake M, Kurosaki T, Yamamoto T, Handa H, Mishina M, Numa S (1983b) Sequence requirement for transcription in vitro of the human corticotropin/beta- lipotropin precursor gene. Eur J Biochem 133: 599–605PubMedGoogle Scholar
  173. Oates E, Herbert E (1984) 5’ sequence of porcine and rat pro-opiomelanocortin mRNA. One porcine and two rat forms. J Biol Chem 259: 7421–7425Google Scholar
  174. Pintar JE, Schachter BS, Herman AB, Durgerian S, Krieger DT (1984) Characterization and localization of proopiomelanocortin messenger RNA in the adult rat testis. Science 225: 632–634PubMedGoogle Scholar
  175. Pittius CW, Kley N, Loeffler JP, Höllt V (1985) Quantitation of proenkephalin A messenger RNA in bovine brain, pituitary and adrenal medulla: correlation between mRNA and peptide levels. EMBO J 4: 1257–1260PubMedGoogle Scholar
  176. Pittius CW, Kley N, Loeffler JP, Höllt V (1987) Proenkephalin B messenger RNA in porcine tissues: characterization, quantification, and correlation with opioid peptides. J Neurochem 48: 586–592PubMedGoogle Scholar
  177. Pollack AE, Wooten GF (1992) Differential regulation of striatal preproenkephalin mRNA by D1 and D2 receptors. Mol Brain Res 12: 111–119PubMedGoogle Scholar
  178. Pritchett DB, Roberts JL (1987) Dopamine regulates expression of the glandular- type kallikrein gene at the transcriptional level in the pituitary. Proc Natl Acad Sci USA 84: 5545–5549PubMedGoogle Scholar
  179. Pruss RM, Stauderman KA (1988) Voltage-regulated calcium channels involved in the regulation of enkephalin synthesis are blocked by phorbol ester treatment. J Biol Chem 263: 13173–13178PubMedGoogle Scholar
  180. Przewlocki R, Haarmann I, Nikolarakis K, Herz A, Höllt V (1988) Prodynorphin gene expression in spinal cord is enhanced after traumatic injury in the rat. Brain Res 464: 37–41PubMedGoogle Scholar
  181. Quach TT, Tang F, Kageyama H, Mocchetti I, Guidotti A, Meek JL, Costa E, Schwartz JP (1984) Enkephalin biosynthesis in adrenal medulla. Modulation of proenkephalin mRNA content of cultured chromaffin cells by 8-bromoadenosine 3’,5’-monophosphate. Mol Pharmacol 26: 255–260PubMedGoogle Scholar
  182. Rattner A, Korner M, Rosen H, Baenerle PA, Citri Y (1991) Nuclear factor KB activates proenkephalin transcription in T-lymphocytes. Mol Cell Biol 11: 1017–1022PubMedGoogle Scholar
  183. Reimer S, Höllt V (1990a) Gabaergic regulation of striatal opioid gene expression. Mol Brain Res 10: 49–54Google Scholar
  184. Reimer S, Höllt V (1990b) Morphine increases proenkephalin gene expression in the adrenal medulla by a central mechanism. In: Quirion R, Jhamandas K, Giounalakis C (eds) The international narcotics research conference (IRNC)’89 Liss, New York, pp 215–218Google Scholar
  185. Reimer S, Sirinathsinghji DJS, Nikolorakis KE, Höllt V (1992) Differential dopaminergic regulation of proenkephalin and prodynorphin mRNAs in the basal ganglia of rats. Mol Brain Res 12: 259–266PubMedGoogle Scholar
  186. Reisine T, Rougon G, Barbet J (1986) Liposome delivery of cAMP-dependent protein kinase inhibitor into intact cells: specific blockade of cAMP-mediated adrenocorticotropin release from mouse anterior pituitary cells. J Cell Biol 102: 1630–1637PubMedGoogle Scholar
  187. Riegel AT, Lu Y, Remenick J, Wolford RG, Berard DS, Hager GL (1991) Proopiomelanocortin gene promoter elements required for constitutive and glucocorticoid-repressed transcription. Mol Endocrinol 5: 1973–1982PubMedGoogle Scholar
  188. Roberts JL, Seeburg PH, Shine J, Herbert E, Baxter JD, Goodman HM (1979) Corticotropin and beta-endorphin: construction and analysis of recombinant DNA complementary to mRNA for the common precursor. Proc Natl Acad Sci USA 76: 2153–2157PubMedGoogle Scholar
  189. Roberts JL, Lundblad JR, Eberwine JH, Fremeau RT, Salton SR, Blum M (1987) Hormonal regulation of POMC gene expression in pituitary. Ann NY Acad Sci 512: 275–285PubMedGoogle Scholar
  190. Romano GJ, Shivers BD, Harlan RE, Howells RD, Pfaff DW (1987) Haloperidol increases proenkephalin mRNA levels in the caudate-putamen of the rat: a quantitative study at the cellular level using in situ hybridization. Brain Res 388: 33–41PubMedGoogle Scholar
  191. Romano GJ, Mobbs CV, Howells RD, Pfaff DW (1989) Estrogen regulation of proenkephalin gene expression in the ventromedial hypothalamus of the rat: temporal qualities and synergism with progesterone. Brain Res Mol Brain Res 5: 51–58PubMedGoogle Scholar
  192. Rosen H, Douglass J, Herbert E (1984) Isolation and characterization of the rat proenkephalin gene. J Biol Chem 259: 14309–14313PubMedGoogle Scholar
  193. Rosen H, Behar O, Abramsky O, Ovadia H (1989) Regulated expression of proenkephalin A in normal lymphocytes. J Immunol 143: 3703–3707PubMedGoogle Scholar
  194. Ruda MA, Iadarola MJ, Cohen LV, Young WS (1988) In situ hybridization histochemistry and immunocytochemistry reveal an increase in spinal dynorphin biosynthesis in a rat model of peripheral inflammation and hyperalgesia. Proc Natl Acad Sci USA 85: 622–626PubMedGoogle Scholar
  195. Schachter BS, Johnson LK, Baxter JD, Roberts JL (1982) Differential regulation by glucocorticoids of proopiomelanocortin mRNA levels in the anterior and intermediate lobes of the rat pituitary. Endocrinology 110: 1442–1444PubMedGoogle Scholar
  196. Schäfer MK-H, Day R, Herman JP, Kwasiborski V, Sladek CD, Akil H, Watson SJ (1989) Effects of electroconvulsive shock on dynorphin in the hypothalamic-neurohypophysial system of the rat. Adv Biosci 75: 599–602Google Scholar
  197. Schäfer MK-H, Day R, Akil H, Watson SJ (1990) Identification of prodynorphin and proenkephalin cells in the neurointermediate lobe of the rat pituitary gland. In: Quirion R, Jhamadas K, Giounalakis C (eds) The international narcotics research conference (IRNC)’89. Liss, New York, pp 231–234Google Scholar
  198. Schwartz JP (1988) Chronic exposure to opiate agonists increases proenkephalin biosynthesis in NG108 cells. Brain Res 427: 141–146PubMedGoogle Scholar
  199. Schwartz JP, Simantov R (1988) Developmental expression of proenkephalin mRNA in rat striatum and in striatal cultures. Brain Res 468: 311–314PubMedGoogle Scholar
  200. Seger MA, van-Eekelen JA, Kiss JZ, Burbach JP, de-Kloet ER (1988) Stimulation of pro-opiomelanocortin gene expression by glucocorticoids in the denervated rat intermediate pituitary gland. Neuroendocrinology 47: 350–357PubMedGoogle Scholar
  201. Seizinger BR, Bovermann K, Höllt V, Herz A (1984a) Enhanced activity of the beta-endorphinergic system in the anterior and neurointermediate lobe of the rat pituitary after chronic treatment with ethanol liquid diet. J Pharmacol Exp Ther 230: 455–461PubMedGoogle Scholar
  202. Seizinger BR, Höllt V, Herz A (1984b) Effects of chronic ethanol treatment on the in vitro biosynthesis of pro-opiomelanocortin and its posttranslational processing to beta-endorphin in the intermediate lobe of the rat pituitary. J Neurochem 43: 607–613PubMedGoogle Scholar
  203. Sherman TG, Civelli O, Douglass J, Herbert E, Burke S, Watson SJ (1986) Hypothalamic dynorphin and vasopressin mRNA expression in normal and Brattleboro rats. Fed Proc 45: 2323–2327PubMedGoogle Scholar
  204. Shiomi H, Watson SJ, Kelsey JE, Akil H (1986) Pretranslational and post- translational mechanisms for regulating beta-endorphin-adrenocorticotropin of the anterior pituitary lobe. Endocrinology 119: 1793–1799PubMedGoogle Scholar
  205. Siegel RE, Eiden LE, Affolter HU (1985) Elevated potassium stimulates encephalin biosynthesis in bovine chromaffin cells. Neuropeptides 6: 543–552PubMedGoogle Scholar
  206. Simantov R, Höllt V (1990) Regulation of proenkephalin A gene expression in aggregating fetal rat brain cells. Cell Mol Neurobiol 11: 245–251Google Scholar
  207. Simard J, Labrie F, Gossard F (1986) Regulation of growth hormone mRNA and pro-opiomelanocortin mRNA levels by cyclic AMP in rat anterior pituitary cells in culture. DNA 5: 263–270PubMedGoogle Scholar
  208. Sivam SP, Hong JS (1986) GABAergic regulation of enkephalin in rat striatum: alterations in Met5-enkephalin level, precursor content and preproenkephalin messenger RNA abundance. J Pharmacol Exp Ther 237: 326–331PubMedGoogle Scholar
  209. Sivam SP, Breese GR, Napier TC, Mueller RA, Hong JS (1986a) Dopaminergic regulation of proenkephalin-A gene expression in the basal ganglia. Natl Inst Drug Abuse Res Monogr Ser 75: 389–392Google Scholar
  210. Sivam SP, Strunk C, Smith DR, Hong JS (1986b) Proenkephalin-A gene regulation in the rat striatum: influence of lithium and haloperidol. Mol Pharmacol 30: 186–191PubMedGoogle Scholar
  211. Sivam SP, Takeuchi K, Li S, Douglass J, Civelli O, Calvetta L, Herbert E, McGinty JF, Hong JS (1988) Lithium increases dynorphin A(1–8) and prodynorphin mRNA levels in the basal ganglia of rats. Brain Res 427: 155–163PubMedGoogle Scholar
  212. Sonnenberg JL, Rauscher FJ, Morgan JI, Curran T (1989) Regulation of proenkephalin by Fos and Jun. Science 246: 1622–1625PubMedGoogle Scholar
  213. Spampinato S, Bachetti T, Canossa M, Ferri S (1990) Prodynorphin messenger RNA expression in the rat anterior pituitary is regulated by estrogen. In: Quirion R, Jhamandas K, Giounalakis C (eds). Liss, New York, pp 211–214Google Scholar
  214. Springhorn JP, Claycomb WC (1989) Preproenkephalin mRNA expression in developing rat heart and in cultured ventricular cardiac muscle cells. Biochem J 258: 73–78PubMedGoogle Scholar
  215. Stachowiak MK, Lee PH, Rigual RJ, Viveros OH, Hong JS (1988) Roles of the pituitary-adrenocortical axis in control of the native and cryptic enkephalin levels and proenkephalin mRNA in the sympathoadrenal system of the rat. Brain Res 427: 263–273PubMedGoogle Scholar
  216. Stalla GK, Stalla J, Huber M, Loeffler JP, Höllt V, von-Werder K, Miiller OA (1988) Ketoconazole inhibits corticotropic cell function in vitro. Endocrinology 122: 618–623PubMedGoogle Scholar
  217. Stalla GK, Stalla J, von-Werder K, Miiller OA, Gerzer R, Höllt V, Jakobs KH (1989a) Nitroimidaxzole derivatives inhibit anterior pituitary cell function apparently by a direct effect on the catalytic subunit of the adenylate cyclase holoenzyme. Endocrinology 125: 699–706PubMedGoogle Scholar
  218. Stalla GK, Stalla J, Mojto J, Oeckler R, Buchfelder M, Müller OA (1989b) Regulation of corticotrophic adenoma cells in vitro. Acta Endocrinol (Copenh) 120 [Suppl 1]: 209–209Google Scholar
  219. Suda T, Tozawa F, Yamada M, Ushiyama T, Tomori N, Sumitomo T, Nakagami Y, Demura H, Shizume K (1988a) Effects of corticotropin-releasing hormone and dexamethasone on proopiomelanocortin messenger RNA level in human corticotroph adenoma cells in vitro. J Clin Invest 82: 110–114PubMedGoogle Scholar
  220. Suda T, Tozawa F, Yamada M, Ushiyama T, Tomori N, Sumitomo T, Nakagami Y, Shizume K (1988b) In vitro study on proopiomelanocortin messenger RNA levels in cultured rat anterior pituitary cells. Life Sci 42: 1147–1152PubMedGoogle Scholar
  221. Suda T, Tozawa F, Ushiyama T, Tomori N, Sumitomo T, Nakagami Y, Yamada M, Demura H, Shizume K (1989) Effects of protein kinase-C-related adrenocorticotropin secretagogues and interleukin-1 on proopiomelanocortin gene expression in rat anterior pituitary cells. Endocrinology 124: 1444–1449PubMedGoogle Scholar
  222. Suda T, Tozawa F, Ushiyama T, Sumitomo T, Yamada M, Demura H (1990) Interleukin-1 stimulates corticotropin-releasing factor gene expression in rat hypothalamus. Endocrinology 126: 1223–1228PubMedGoogle Scholar
  223. Takahashi H, Hakamata Y, Watanabe Y, Kikuno R, Miyata T, Numa S (1983) Complete nucleotide sequence of the human corticotropin-beta-lipotropin precursor gene. Nucleic Acids Res 11: 6847–6858PubMedGoogle Scholar
  224. Tang F, Costa E, Schwartz JP (1983) Increase of proenkephalin mRNA and enkephalin content of rat striatum after daily injection of haloperidol for 2 to 3 weeks. Proc Natl Acad Sci USA 80: 3841–3844PubMedGoogle Scholar
  225. Tempel A (1990) Morphine-induced downregulation of mu opioid receptors and peptide synthesis in neonatal rat brain. In: Van Ree J, Mulder AH, Wiegant VM, van Wimersma Greidanus TB (eds) New leads in opioid research. Elseveier, Amsterdam, pp 99–101Google Scholar
  226. Terao M, Watanabe Y, Mishina M, Numa S (1983) Sequence requirement for transcription in vivo of the human preproenkephalin A gene. EMBO J 2: 2223–2228PubMedGoogle Scholar
  227. Therrien M, Drouin J (1991) Pituitary proopiomelanocortin gene expression requires synergistic interaction of several regulatory elements.Mol Cell Biol 11: 3492–3503Google Scholar
  228. Thiele EA, Eipper BA (1990) Effect of secretagogues on components of the secretory system in AtT-20 cells. Endocrinology 126: 809–817PubMedGoogle Scholar
  229. Tomiko SA, Taraskevich PS, Douglas WW (1983) GABA acts directly on cells of pituitary pars intermedia to alter hormone output. Nature 301: 706–707PubMedGoogle Scholar
  230. Tozawa F, Suda T, Yamada M, Ushiyama T, Tomori N, Sumitomo T, Nakagami Y, Demura H, Shizume K (1988) Insulin-induced hypoglycemia increases pro-opiomelanocortin messenger ribonucleic acid levels in rat anterior pituitary gland. Endocrinology 122: 1231–1235PubMedGoogle Scholar
  231. Tremblay Y, Tretjakoff I, Peterson A, Antakly T, Zhang CX, Drouin J (1988) Pituitary-specific expression and glucocorticoid regulation of a pro-opiomelanocortin fusion gene in transgenic mice. Proc Natl Acad Sci USA 85: 8890–8894PubMedGoogle Scholar
  232. Uhl GR, Ryan JP, Schwartz JP (1988) Morphine alters preproenkephalin gene expression. Brain Res 459: 391–397PubMedGoogle Scholar
  233. Uhler M, Herbert E, D’Eustachio P, Ruddle FD (1983) The mouse genome contains two nonallelic pro-opiomelanocortin genes. J Biol Chem 258: 9444–9453PubMedGoogle Scholar
  234. Vernier P, Julien JF, Rataboul P, Fourrier O, Feuerstein C, Mallet J (1988) Similar time course changes in striatal levels of glutamic acid decarboxylase and proenkephalin mRNA following dopaminergic deafferentation in the rat. J Neurochem 51: 1375–1380PubMedGoogle Scholar
  235. Vilijn MH, Vaysse PJ, Zukin RS, Kessler JA (1988) Expression of preproenkephalin mRNA by cultured astrocytes and neurons. Proc Natl Acad Sci USA 85: 6551–6555PubMedGoogle Scholar
  236. Von Dreden G, Höllt V (1988) Vasopressin potentiates β-endorphin release but not the increase in the mRNA for proopiomelanocortin induced by corticotropin releasing factor in rat pituitary cells. Acta Endocrinol (Copenh) 117 [Suppl 287]: 124–124Google Scholar
  237. Von Dreden G, Loeffler JP, Grimm C, Höllt V (1988) Influence of calcium ions on proopiomelanocortin mRNA levels in clonal anterior pituitary cells. Neuroendocrinology 47: 32–37Google Scholar
  238. Vyas S, Bishop JF, Gehlert DR, Patel J (1990) Effects of protein kinase C down- regulation on secretory events and proopiomelanocortin gene expression in anterior pituitary tumor (AtT-20) cells. J Neurochem 54: 248–255PubMedGoogle Scholar
  239. Wan DC, Livett BG (1989) Induction of phenylethanolamine N-methyltransferase mRNA expression by glucocorticoids in cultured bovine adrenal chromaffin cells. Eur J Pharmacol 172: 107–115PubMedGoogle Scholar
  240. Wan DC, Scanlon D, Choi CL, Bunn SJ, Howe PR, Livett BG (1989a) Co-localization of RNAs coding for phenylethanolamine N-methyltransferase and proenkephalin A in bovine and ovine adrenals. J Auton Nerv Syst 26: 231–240PubMedGoogle Scholar
  241. Wan DC, Marley PD, Livett BG (1989b) Histamine activates proenkephalin A mRNA but not phenylethanolamine N-methyltransferase mRNA expression in cultured bovine adrenal chromaffin cells. Eur J Pharmacol 172: 117–129PubMedGoogle Scholar
  242. Wand GS (1990) Differential regulation of anterior pituitary corticotrope function is observed in vivo but not in vitro in two lines of ethanol-sensitive mice. Alcoholism 14: 100–106PubMedGoogle Scholar
  243. Wand JA, Eiden LE (1988) Calcium requirements for barium stimulation of enkephalin and vasoactive intestinal peptide biosynthesis in adrenomedullary chromaffin cells. Neuropeptides 11: 39–45Google Scholar
  244. Waschek JA, Dave JR, Eskay RL, Eiden LE (1987) Barium distinguishes separate calcium targets for synthesis and secretion of peptides in neuroendocrine cells. Biochem Biophys Res Commun 146: 495–501PubMedGoogle Scholar
  245. Weihe E, Millan MJ, Höllt V, Nohr D, Herz A (1989) Induction of the gene encoding pro-dynorphin by experimentally induced arthritis enhances staining for dynorphin in the spinal cord of rats. Neuroscience 31: 77–95PubMedGoogle Scholar
  246. White JD, Gall CM, McKelvy JF (1987) Enkephalin biosynthesis and enkephalin gene expression are increased in hippocampal mossy fibers following a unilateral lesion of the hilus. J Neurosci 7: 753–759PubMedGoogle Scholar
  247. Wiemann JN, Clifton DK, Steiner RA (1989) Pubertal changes in gonadotropin-releasing hormone and proopiomelanocortin gene expression in the brain of the male rat. Endocrinology 124: 1760–1767PubMedGoogle Scholar
  248. Wilcox JN, Roberts JL (1985) Estrogen decreases rat hypothalamic proopiomelanocortin messenger ribonucleic acid levels. Endocrinology 117: 2392–2396PubMedGoogle Scholar
  249. Xie CW, Lee PH, Takeuchi K, Owyang V, Li SJ, Douglass J, Hong JS (1989) Single or repeated electroconvulsive shocks alter the levels of prodynorphin and proenkephalin mRNAs in rat brain. Brain Res Mol Brain Res 6: 11–19PubMedGoogle Scholar
  250. Xie C-W, McGinty JF, Lee PHK, Mitchell CL, Hong J-S (1991) A glutamate antagonist blocks perforant stimulation-induced reduction of dynorphin peptide and prodynorphin mRNA levels in rat hippocampus. Brain Res 562: 243–250PubMedGoogle Scholar
  251. Yoshikawa K, Sabol SL (1986) Expression of the enkephalin precursor gene in C6 rat glioma cells: regulation by beta-adrenergic agonists and glucocorticoids. Brain Res 387: 75–83PubMedGoogle Scholar
  252. Yoshikawa K, Hong JS, Sabol SL (1985) Electroconvulsive shock increases preproenkephalin messenger RNA abundance in rat hypothalamus. Proc Natl Acad Sci USA 82: 589–593PubMedGoogle Scholar
  253. Yoshikawa K, Maruyama K, Aizawa T, Yamamoto A (1989a) A new species of enkephalin precursor mRNA with a distinct 5’-untranslated region in haploid germ cells. FEBS Lett 246: 193–196PubMedGoogle Scholar
  254. Yoshikawa K, Aizawa T, Nozawa A (1989b) Phorbol ester regulates the abundance of enkephalin precursor mRNA but not of amyloid beta-protein precursor mRNA in rat testicular peritubular cells. Biochem Biophys Res Commun 161: 568–575PubMedGoogle Scholar
  255. Young WS, Bonner TI, Brann MR (1986) Mesencephalic dopamine neurons regulate the expression of neuropeptide mRNAs in the rat forebrain. Proc Natl Acad Sci USA 83: 9827–9831PubMedGoogle Scholar
  256. Zheng M, Yang SG, Zou G (1988) Electro-acupuncture markedly increases proenkephalin mRNA in rat striatum and pituitary. Sci sin [B] 31: 81–86Google Scholar
  257. Zurawski G, Benedik M, Kamb BJ, Abrams JS, Zurawski SM, Lee FD (1986) Activation of mouse T-helper cells induces abundant preproenkephalin mRNA synthesis. Science 232: 772–775PubMedGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • V. Höllt

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