Opioids pp 423-447 | Cite as

Biosynthesis of Enkephalins and Proenkephalin-Derived Peptides

  • J. Rossier
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 104 / 1)


The enkephalins [Met5]- and [Leu5]enkephalin were isolated in 1975 by Hughes et al. Since then, numerous other opioid peptides have been characterized although none of these are found in levels comparable to [Met5]enkephalin in brain tissue (see Table 1). Brain levels of prodynorphin and proopiomelanocortin-derived peptides, for example, are at least one order of magnitude lower than those of [Met5]enkephalin. When compared to other nonopioid peptides, the levels of [Met5]enkephalin are of the same order as two other widely distributed peptides, CCK8 and somatostatin (see review in Crawley 1985).


Adrenal Medulla Opioid Peptide Chromaffin Granule Bovine Adrenal Medulla Glycyl Residue 
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© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • J. Rossier

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