Opioids pp 585-624 | Cite as

Coexistence of Opioid Peptides with Other Neurotransmitters

  • R. Elde
  • T. Hökfelt
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 104 / 1)


The opioid peptides were discovered during the early, explosive period of neuropeptide research. A great deal of excitement surrounded this research, in part because the path that led to the discovery of the opioids was, and remains, unique. Opioids have been the only neuropeptides isolated for their ability to bind to and act at an already well–characterized receptor. In addition, the function of these receptors was known in several neuronal systems, and the effects caused by either the alkaloid opiates or the newly characterized opioid peptides could be blocked by existing antagonists, such as naloxone. Thus, even at its birth, the field of opioid peptide research was more advanced than for any other neuropeptide.


Tyrosine Hydroxylase Vasoactive Intestinal Peptide Chromaffin Cell Vasoactive Intestinal Polypeptide Opioid Peptide 
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© Springer-Verlag Berlin Heidelberg 1993

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  • R. Elde
  • T. Hökfelt

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