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Opioids pp 53-78 | Cite as

Use of Organ Systems for Opioid Bioassay

  • J. A. M. Smith
  • F. M. Leslie
Chapter
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 104 / 1)

Abstract

The fundamental principle of bioassay is that interaction of an agonist drug with a specific cellular receptor leads to the production of a biological response. Since this involves a physiological endpoint, receptors can be examined in their native, functional state. This contrasts to radioligand binding assays, which are often carried out under nonphysiological conditions, and can only provide information about the receptor ligand recognition site.

Keywords

Opioid Receptor Opioid Peptide Opiate Receptor Opioid Agonist Agonist Potency 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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  • J. A. M. Smith
  • F. M. Leslie

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