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Opioids pp 145-188 | Cite as

Opioid Receptor-G Protein Interactions: Acute and Chronic Effects of Opioids

  • B. M. Cox
Chapter
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 104 / 1)

Abstract

It has been accepted for several years that opioid action mediated through μ- and δ-type opioid receptors requires the interaction of the agonist- occupied receptor with a guanine nucleotide binding protein (G protein). Accumulating evidence suggests that a similar mechanism is an essential component of κ-type opioid receptor function. In this chapter, we will discuss the evidence supporting these conclusions and review similarities and differences between opioid receptor-G protein interactions and the functions of other G protein-linked receptor systems. The evidence that tolerance to opioid agonist actions and the development of dependence on opioid agonist after chronic exposure might also be related to modified interactions between receptor and G protein, and also to changes in the concentrations of individual forms of G proteins, will also be considered.

Keywords

Opioid Receptor Adenylyl Cyclase Guanine Nucleotide Opiate Receptor Opioid Agonist 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • B. M. Cox

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