Advertisement

Complementation Between Defective Oncogenic Viruses

  • Fred Rapp
Chapter
Part of the Recent Results in Cancer Research / Fortschritte der Krebsforschung / Progrès dans les recherches sur le cancer book series (RECENTCANCER, volume 6)

Abstract

Complementation involves functional interaction between two viruses which results in replication under normally inhibitory conditions. A virus which requires complementation for replication is usually defective in some portion of its genome. However, some viruses competent to grow unilaterally in one cell may be incompetent in a second cell and thus require a second virus to furnish help for some step in the replicative cycle. Though complementation has been studied extensively with bacterial viruses (2, 20, 40, 43) and with one plant virus (15, 33), relatively few such studies have been carried out with animal viruses.

Keywords

Tumor Antigen Human Embryonic Kidney Cell Simian Cell Adenovirus Type Helper Virus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Beardmore, W. B., Havlick, M. J., Serafini, A., and McLean, I. W., Jr.: Interrelationship of Adenovirus (Type 4) and Papovavirus (SV40) in Monkey Kidney Cell Cultures. J. Immunol. 95, 422–435 (1965).PubMedGoogle Scholar
  2. 2.
    Benzer, S.: Fine Structure of a Genetic Region in Bacteriophage. Proc. Nat. Acad. Sci. U.S. 41, 344–354 (1955).CrossRefGoogle Scholar
  3. 3.
    Black, P. H., and Todaro, G. J.: In vitro Transformation of Hamster and Human Cells with the Adeno 7-SV40 Hybrid Virus. Proc. Nat. Acad. Sci. U.S. 54, 374–381 (1965).CrossRefGoogle Scholar
  4. 4.
    Boeyé, A., Melnick, J. L., and Rapp, F.: Adenovirus-SV40 “Hybrids”: Plaque Purification into Lines in which the Determinant of the SV40 Tumor Antigen is Lost or Retained. Virology, 26, 511–512 (1965).PubMedCrossRefGoogle Scholar
  5. 5.
    Boeyé, A., Melnick, J. L., and Rapp, F.: SV40-Adenovirus “Hybrids”; Presence of Two Genotypes and the Requirement of Their Complementation for Viral Replication. Virology, 28, 56–70 (1966).PubMedCrossRefGoogle Scholar
  6. 6.
    Butel, J. S., Melnick, J. L., and Rapp, F.: Quantitative Aspects of Complementation Between Adenoviruses and a PARA (Defective SV40) — Adenovirus “Hybrid” Population. Submitted for publication, 1966.Google Scholar
  7. 7.
    Butel, J. S., and Rapp, F.: The Effect of Arabinofuranosylcytosine on the Growth Cycle of Simian Virus 40. Virology, 27, 490–495 (1965).PubMedCrossRefGoogle Scholar
  8. 8.
    Butel, J. S., and Rapp, F.: Replication in Simian Cells of Defective Viruses in an SV40-Adenovirus “Hybrid” Population. J. Bact. 91, 278–284 (1966).PubMedGoogle Scholar
  9. 9.
    Easton, J. M., and Hiatt, C. W.: Possible Incorporation of SV40 Genome Within Capsid Proteins of Adenovirus 4. Proc. Nat. Acad. Sci. U.S. 54, 1100–1104 (1965).CrossRefGoogle Scholar
  10. 10.
    Easton, J. M., and Hiatt, C. W.: Simian Virus 40: Replication in the Presence of Specific Antiserum and Adenovirus 4. Science, 151, 582–583 (1966).PubMedCrossRefGoogle Scholar
  11. 11.
    Feldman, L. A., Butel, J. S., and Rapp, F.: Interaction of Papovavirus SV40 and Adenoviruses. I. Induction of Adenovirus Tumor Antigen During Abortive Infection of Simian Cells. J. Bact., in press, 1966.Google Scholar
  12. 12.
    Feldman, L. A., Melnick, J. L., and Rapp, F.: Influence of SV40 Genome on the Replication of an Adenovirus-SV40 “Hybrid” Population. J. Bact. 90, 778–782 (1965).PubMedGoogle Scholar
  13. 13.
    Hanafusa, H., Hanafusa, T., and Rubin, H.: Analysis of the Defectiveness of Rous Sarcoma Virus. II. Specification of RSV Antigenicity by Helper Virus. Proc. Nat. Acad. Sci. U.S. 51, 41–48 (1964).CrossRefGoogle Scholar
  14. 14.
    Huebner, R. J., Chanock, R. M., Rubin, B. A., and Casey, M. J.: Induction by Adenovirus Type 7 of Tumors in Hamsters Having the Antigenic Characteristics of SV40 Virus. Proc. Nat. Acad. Sci. U.S. 52, 1333–1340 (1964).CrossRefGoogle Scholar
  15. 15.
    Kassanis, B., and Nixon, H. L.: Activation of One Tobacco Necrosis Virus by Another. J. Gen. Microbiol. 25, 459–471 (1961).PubMedGoogle Scholar
  16. 16.
    Malmgren, R. A., Rabson, A. S., Carney, P. G., and Paul, F. J. Immunofluorescence of Green Monkey Kidney Cells Infected with Adenovirus 12 and Adenovirus 12 Plus Simian Virus 40. J. Bact. 91, 262–265 (1966).PubMedGoogle Scholar
  17. 17.
    Melnick, J. L., Rapp, F., and Butel, J. S.: Oncogenicity of PARA (Defective SV40)-Adenovirus. Proc. Am. Assoc. Cancer Res., in press (1966).Google Scholar
  18. 18.
    Melnick, J. L., Mayor, H. D., Smith, K. O., and Rapp, F.: Association of 20-Millimicron Particles with Adenoviruses. J. Bact. 90, 271–274 (1965).PubMedGoogle Scholar
  19. 19.
    Melnick, J. L., and Rapp, F.: Effect of Inhibitors on Induction of SV40 Tumor Antigen by an Adenovirus-SV40 Hybrid. Arch. f. d. ges. Virusforsch. 17, 424–435 (1965).CrossRefGoogle Scholar
  20. 20.
    Nishihara, M., and Romig, W. R.: Temperature-Sensitive Mutants of Bacillus subtilis Bacteriophage SP3. II. In vivo Complementation Studies. J. Bact. 88, 1230–1239 (1964).PubMedGoogle Scholar
  21. 21.
    O’Conor, G. T., Rabson, A. S., Berezesky, I. K., and Paul, F. J.: Mixed Infection with Simian Virus 40 and Adenovirus 12. J. Nat. Cancer Inst. 31, 903–917 (1963).PubMedGoogle Scholar
  22. 22.
    O’Conor, G. T., Rabson, A. S., Malmgren, R. A., Berezesky, I. K., and Paul, F. J.: Morphologic Observations of Green Monkey Kidney Cells after Single and Double Infection with Adenovirus 12 and Simian Virus 40. J. Nat. Cancer Inst. 34, 679–693 (1965).PubMedGoogle Scholar
  23. 23.
    Oda, M.: Rescue of Dermovaccinia Abortive Infection by Neurovaccinia in L Cells. Virology, 25, 665–666 (1965).CrossRefGoogle Scholar
  24. 24.
    Pope, J. H., and Rowe, W. P.: Detection of Specific Antigen in SV40-Transformed Cells by Immunofluorescence. J. Exp. Med. 120, 121–128 (1964).PubMedCrossRefGoogle Scholar
  25. 25.
    Rabson, A. S., O’Conor, G. T., Berezesky, I. K., and Paul, F. J.: Enhancement of Adenovirus Growth in African Green Monkey Kidney Cell Cultures by SV40. Proc. Soc. Exp. Biol. Med. 116, 187–190 (1964).PubMedGoogle Scholar
  26. 26.
    Rapp, F.: New Surface Antigens in Cells Transformed by Papovavirus SV40 and Preparation of Specific Cytotoxic Antibody. Nat. Cancer Inst. Monograph, in press (1965).Google Scholar
  27. 27.
    Rapp, F. (1966). Unpublished experiments.Google Scholar
  28. 28.
    Rapp, F., Butel, J. S., Feldman, L. A., Kitahara, T., and Melnick, J. L.: Differential Effects of Inhibitors on the Steps Leading to the Formation of SV40 Tumor and Virus Antigens. J. Exp. Med. 121, 935–944 (1965).PubMedCrossRefGoogle Scholar
  29. 29.
    Rapp, F., Butel, J. S., and Melnick, J. L.: Virus-Induced Intranuclear Antigens in Cells Transformed by Papovavirus SV40. Proc. Soc. Exp. Biol. Med. 116, 1131–1135 (1964).PubMedGoogle Scholar
  30. 30.
    Rapp, F., Butel, J. S., and Melnick, J. L.: SV40-Adenovirus “Hybrid” Populations: Transfer of SV40 Determinants from One Type of Adenovirus to Another. Proc. Nat. Acad. Sci. U.S. 54, 717–724 (1965).CrossRefGoogle Scholar
  31. 31.
    Rapp, F., Melnick, J. L., Butel, J. S., and Kitahara, T.: The Incorporation of SV40 Genetic Material into Adenovirus 7 as Measured by Intranuclear Synthesis of SV40 Tumor Antigen. Proc. Nat. Acad. Sci. U.S. 52, 1348–1352 (1964).CrossRefGoogle Scholar
  32. 32.
    Rapp, F., Tevethia, S. S., and Melnick, J. L.: Papovavirus SV40 Transplantation Immunity Conferred by an Adenovirus-SV40 Hybrid. J. Nat. Cancer Inst., in press (1966).Google Scholar
  33. 33.
    Reichmann, M. E.: The Satellite Tobacco Necrosis Virus: A Single Protein and Its Genetic Code. Proc. Nat. Acad. Sci. U.S. 52, 1009–1017 (1964).CrossRefGoogle Scholar
  34. 34.
    Rowe, W. P.: Studies of Adenovirus-SV40 Hybrid Viruses. III. Transfer of SV40 Gene Between Adenovirus Types. Proc. Nat. Acad. Sci. U.S. 54, 711–717 (1965).CrossRefGoogle Scholar
  35. 35.
    Rowe, W. P., and Baum, S. G.: Evidence for a Possible Genetic Hybrid Between Adenovirus Type 7 and SV40 Viruses. Proc. Nat. Acad. Sci. U.S. 52, 1340–1347 (1964).CrossRefGoogle Scholar
  36. 36.
    Rowe, W. P., and Baum, S. G.: Studies of Adenovirus-SV40 Hybrid Viruses. II. Defectiveness of the Hybrid Particles. J. Exp. Med. 122, 955–966 (1965).PubMedCrossRefGoogle Scholar
  37. 37.
    Rowe, W. P., Baum, S. G., Pugh, W. E., and Hoggan, M. D.: Studies of Adenovirus-SV40 Hybrid Viruses. I. Assay System and Further Evidence for Hybridization. J. Exp. Med. 122, 943–954 (1965).PubMedCrossRefGoogle Scholar
  38. 38.
    Rubin, H.: Virus Defectiveness and Cell Transformation in the Rous Sarcoma. J. Cell. Comp. Physiol. 64, 173–180 (1964).CrossRefGoogle Scholar
  39. 39.
    Schell, K., Lane, W. T., Casey, M. J., and Huebner, R. J.: Potentiation of Oncogenecity of Adenovirus Type 12 Grown in African Green Monkey Kidney Cell Cultures Preinfected with SV40 Virus: Persistence of Both T Antigens in the Tumors and Evidence for Possible Hybridization. Proc. Nat. Acad. Sci. U.S. 55, 81–88 (1966).CrossRefGoogle Scholar
  40. 40.
    Tessman, E. S.: Complementation Groups in Phage S13. Virology, 25, 303–321 (1965).PubMedCrossRefGoogle Scholar
  41. 41.
    Tevethia, S. S., Katz, M., and Rapp, F.: New Surface Antigens in Cells Transformed by Simian Papovavirus SV40. Proc. Soc. Exp. Biol. Med. 119, 896–901 (1965).PubMedGoogle Scholar
  42. 42.
    Tevethia, S. S., and Rapp, F.: Demonstration of New Surface Antigens in Cells Transformed by Papovavirus SV40 by Cytotoxic Tests. Proc. Soc. Exp. Biol. Med. 120, 455–458 (1965).PubMedGoogle Scholar
  43. 43.
    Valentine, R. C., Engelhardt, D. L., and Zinder, N. D.: Host-Dependent Mutants of the Bacteriophage f2. II. Rescue and Complementation of Mutants. Virology, 23, 159 – 163 (1964).PubMedCrossRefGoogle Scholar
  44. 44.
    Yang, C.-s., and Melnick, J. L.: Contamination of Adenovirus Stocks with SV40 (Papovavirus Group). Proc. Soc. Exp. Biol. Med. 113, 339–343. (1963).PubMedGoogle Scholar

Copyright information

© Springer-Verlag New York Inc. 1966

Authors and Affiliations

  • Fred Rapp
    • 1
  1. 1.Department of Virology and EpidemiologyBaylor University College of MedicineHoustonUSA

Personalised recommendations