Relative Growth and Oncogenic Potential of Normal, Malignant, and Virus-Transformed Euploid Cells of Dwarf Species of Hamster

Discussion to Dr. Paul Moorhead’s Presentation on Cytogenetic Alterations During Malignant Progression
  • George Yerganian
Part of the Recent Results in Cancer Research / Fortschritte der Krebsforschung / Progrès dans les recherches sur le cancer book series (RECENTCANCER, volume 6)


Numerical and structural alterations of the karyotype are secondary phenomena featured among many, if not all, continuously propagated normal, malignant, and virus-transformed cell lines. Dr. Moorhead has described the varied events during in vitro progression of human and Syrian hamster virus-transformed cells. His efforts to associate cytogenetic alterations with increased oncogenicity must, however, be restricted to the species employed for reasons I will describe below. The degree of aneuploidy need not be extensive, in order for experimental cells to proliferate more rapidly, or to attain the status of a permanent cell line. I sense that Dr. Moorhead will agree to the statement that a subtle, stable pseudodiploid condition is more conducive to the development of a cell or tumor line than many complex heteroploid conditions (Yerganian, et al., 1960; Moorhead, 1965).


Syrian Hamster Clonal Line Chinese Hamster Cell Cheek Pouch Cytogenetic Alteration 
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© Springer-Verlag New York Inc. 1966

Authors and Affiliations

  • George Yerganian
    • 1
  1. 1.Laboratories of Cytogenetics, The Children’s Cancer Research FoundationHarvard University Medical SchoolBostonUSA

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