Relative Growth and Oncogenic Potential of Normal, Malignant, and Virus-Transformed Euploid Cells of Dwarf Species of Hamster
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Numerical and structural alterations of the karyotype are secondary phenomena featured among many, if not all, continuously propagated normal, malignant, and virus-transformed cell lines. Dr. Moorhead has described the varied events during in vitro progression of human and Syrian hamster virus-transformed cells. His efforts to associate cytogenetic alterations with increased oncogenicity must, however, be restricted to the species employed for reasons I will describe below. The degree of aneuploidy need not be extensive, in order for experimental cells to proliferate more rapidly, or to attain the status of a permanent cell line. I sense that Dr. Moorhead will agree to the statement that a subtle, stable pseudodiploid condition is more conducive to the development of a cell or tumor line than many complex heteroploid conditions (Yerganian, et al., 1960; Moorhead, 1965).
KeywordsSyrian Hamster Clonal Line Chinese Hamster Cell Cheek Pouch Cytogenetic Alteration
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