Transformation of Human Cells by Oncogenic Virus SV40

  • Anthony J. Girardi
  • Fred C. Jensen
Part of the Recent Results in Cancer Research / Fortschritte der Krebsforschung / Progrès dans les recherches sur le cancer book series (RECENTCANCER, volume 6)


To date, the only viruses that have been shown capable of transforming human cells in vitro are Simian Virus 40 (13, 16, 20, 24) and a hybrid strain or adenovirus type 7-SV40 (strain LLE-46) (4). This latter virus is a human strain of adenovirus which has apparently acquired a portion of the SV40 genome during laboratory passage. By currently accepted standards, infection of human tissue with Rous sarcoma or wart viruses has not led to transformation.


Infectious Virus Simian Virus Contact Inhibition Virus Yield Adenovirus Type 
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Copyright information

© Springer-Verlag New York Inc. 1966

Authors and Affiliations

  • Anthony J. Girardi
    • 1
  • Fred C. Jensen
    • 1
  1. 1.The Wistar InstitutePhiladelphiaUSA

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