Immunologic Attack on Neoplasia

  • M. R. Hilleman
Part of the Recent Results in Cancer Research / Fortschritte der Krebsforschung / Progrès dans les recherches sur le cancer book series (RECENTCANCER, volume 6)


In the simplest view, protection against cancer involves two different possibilities: first, protecting the host against those invaders from without which initiate the neoplastic process and second, protecting the host against the invaders from within which are the cancer cells themselves. The immunologic approach affords the means for attack both upon the invaders from without and the invaders from within. For convenience the immunologic approaches may be divided into the causative agent-specific, the tumor antigen-specific, and the nonspecific.


Tumor Antigen Human Leukemia Immunologic Tolerance Rous Sarcoma Virus Polyoma Virus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Epstein, M. A., Woodall, J. P., and Thomson, A. D., 1964: Lymphoblastic lymphoma in bone-marrow of African green monkeys (Cercopithecus Aethiops) inoculated with biopsy material from a child with Burkitt’s lymphoma. Lancet 2, 288–291.PubMedCrossRefGoogle Scholar
  2. 2.
    McAllister, R. R., B.H., Landing, and Goodheart, C. R., 1964: Isolation of adenoviruses from neoplastic and non-neoplastic tissues of children. Lab. Invest. 13, 894–901.PubMedGoogle Scholar
  3. 3.
    Bell, T. M, Massie, A., Ross, M. G. R., and Williams, M. C., 1964: Isolation of a reovirus from a case of Burkitt’s lymphoma. Brit. Med. J. 1, 1212–1213.PubMedCrossRefGoogle Scholar
  4. 4.
    Epstein, M. A., Achong, B. G., and Barr, Y. M., 1964: Virus particles in cultured lymphoblasts from Burkitt’s lymphoma. Lancet 1, 702–703.PubMedCrossRefGoogle Scholar
  5. 5.
    Dalldorf, G., and Bergamini, F., 1964: Unidentified, filtrable agents isolated from African children with malignant lymphomas. Proc. Nat. Acad. Sci. 51, 263–265.PubMedCrossRefGoogle Scholar
  6. 6.
    Burger, C. L., Harris, W. W., Harris, N. G., Bartlett, R. M, and Kniseley, R. M., 1964: Virus-like particles in human leukemic plasma. Proc. Soc. Exp. Biol. Med. 115, 151–156.PubMedGoogle Scholar
  7. 7.
    Smith, K. O., M., Benyesh-Melnick, and Fernbach, D. J., 1964: Studies on human leukemia. II. Structure and quantitation of myxovirus-like particles associated with human leukemia. J. Nat. Cancer Inst. 33, 5 57–570.Google Scholar
  8. 8.
    Dmochowski, L., 1965: Electron microscopic observations of leukemia in animals and in man. Cancer Res. 25, 1654–1671.PubMedGoogle Scholar
  9. 9.
    Epstein, M. A., Barr, Y. M., and Achong, B. G., 1965: Studies with Burkitt’s lymphoma. Methodological Approaches to the Study of Leukemias, V. Defendi (Ed.). Wistar Institute Symposium Monograph No. 4, 69–79.Google Scholar
  10. 10.
    Stewart, S. E., Landon,J., Lovelace, G., and Parker, G., 1965: Burkitt tumor: Brain lesions in hamsters induced with an extract from the SL-1 cell line. Methodological Approaches to the Study of Leukemias, V. Defendi (Ed.). Wistar Institute Symposium Monograph No. 4, 93–101.Google Scholar
  11. 11.
    Henle, G., and Henle, W., 1965: Interference in the detection of viral carrier states. Methodological Approaches to the Study of Leukemias, V. Defendi (Ed.). Wistar Institute Symposium Monograph No. 4, 83–90.Google Scholar
  12. 12.
    O’Conor, G. T., and Rabson, A. S., 1965: Herpes-like particles in an American lymphoma: Preliminary note. J. Nat. Cancer Inst. 35, 899–903.Google Scholar
  13. 13.
    Anderson, D. R., 1965: Subcellular particles associated with human leukemia as seen with the electron microscope. Methodological Approaches to the Study of Leukemias, V. Defendi (Ed.). Wistar Institute Symposium Monograph No. 4, 113–141.Google Scholar
  14. 14.
    Murphy, W. H., Ertel, I. J, and Zarafonetis, C. J. D, 1965: Virus studies of human leukemia. Cancer 18, 1329–1344.PubMedCrossRefGoogle Scholar
  15. 15.
    Grace, J. T., Jr., Horoszewicz, J. S., Stim, T. B., Mirand, E. A., and James, C., 1965: Mycoplasmas (PPLO) and human leukemia and lymphoma. Cancer 18, 1369–1376.PubMedCrossRefGoogle Scholar
  16. 16.
    Armstrong, D., Henle, G., Somerson, N. L., and Hayflick, L., 1965: Cytopathogenic mycoplasmas associated with two human tumors. I. Isolation and biological aspects. J. Bact. 90, 418–424.PubMedGoogle Scholar
  17. 17.
    Hummeler, K., Tomassini, N., and Hayflick, L., 1965: Ultrastructure of a mycoplasma (Negroni) isolated from human leukemia. J. Bact. 90, 517–523.PubMedGoogle Scholar
  18. 18.
    Hayflick, L., 1965: Mycoplasmas and human leukemia. Methodological Approaches to the Study of Leukemias, V. Defendi (Ed.). Wistar Institute Symposium Monograph No. 4, 157–164.Google Scholar
  19. 19.
    Dmochowski, L., Taylor, H. G., Grey, C. E., Dreyer, D. A., Sykes, J. A., Langford, P. L., Rogers, T., Shullenberger, C. C., and Howe, C. D., 1965: Viruses and mycoplasma (PPLO) in human leukemia. Cancer 18, 1345–1368.PubMedCrossRefGoogle Scholar
  20. 20.
    Burmester, B. R., Walter, W. G., and Fontes, A. F., 1957: The immunological response of chickens after treatment with several vaccines of visceral lymphomatosis. Poultry Sci. 36, 79–87.Google Scholar
  21. 21.
    Ledent, R., et L. Wellens: La slection et la surveillance des conducteurs de tramways de Lige. Trav. Hum. 3, 385406 (1935)., M. A., and Rauscher, F. J., 1961: A simple method for the preparation of potent chicken anti-Rous sarcoma virus serum. J. Nat. Cancer Inst. 26, 519–522.PubMedGoogle Scholar
  22. 22.
    Hughes, W. F., Watanabe, D. H., and Rubin, H., 1963: The development of a chicken flock apparently free of leukosis virus. Avian Dis. 7, 154–165.CrossRefGoogle Scholar
  23. 23.
    Jensen, F. C., Girardi, A. J., Gilden, R. V., and Koprowski, H., 1964: Infection of human and simian tissue cultures with Rous sarcoma virus. Proc. Nat. Acad. Sci. 52, 53–59.PubMedCrossRefGoogle Scholar
  24. 24.
    Friend, C., 1959: Immunological relationships of a filterable agent causing a leukemia in adult mice. I. The neutralization of infectivity by specific antiserum. J. Exp. Med. 109, 217–228.PubMedCrossRefGoogle Scholar
  25. 25.
    Fink, M. A., and Rauscher, F. J., 1964: Immune reactions to a murine leukemia virus. I. Induction of immunity to infection with virus in the natural host. J. Nat. Cancer Inst. 32, 1075–1082.PubMedGoogle Scholar
  26. 26.
    Fink, M. A., Rauscher, F. J., and Chirigos, M., 1965: Some immune reactions of murine leukemia viruses demonstrable within a completely isologous system. Presented at Workshop on Prospects for Control of Viral-Induced Tumors by Immunologic Methods and Chemotherapy, held by Subcommittee on Carcinogenesis and Prevention, National Advisory Cancer Council. June 18–19, 1965, Bethesda, Maryland. J. Nat. Cancer Inst. To be published. Google Scholar
  27. 27.
    Sinkovics, J. G., Bertin, B. A., and Howe, C. D., 1965: Some properties of the photo-dynamically inactivated Rauscher mouse leukemia virus. Cancer Res. 25, 624–627.PubMedGoogle Scholar
  28. 28.
    Eddy, B., Stewart, S. E., and Touchette, R., 1959: Effect of immunization of adult female hamsters on the latency of infection in offspring inoculated with the SE polyoma virus. Fed. Proc. 18, 565.Google Scholar
  29. 29.
    Eddy, B. E., Grubbs, G. E., and Young, R. D., 1964: Tumor immunity in hamsters infected with adenovirus type 12 or simian virus 40. Proc. Soc. Exp. Biol. and Med. 117, 575–579.Google Scholar
  30. 30.
    Deichman, G. I., and Kluchareva, T. E., 1964: Prevention of tumour induction in SV40 infected hamsters. Nature 202, 1126–1128.PubMedCrossRefGoogle Scholar
  31. 31.
    Saito, J. K., McKercher, D. G., and Castrucci, G., 1964: Attenuation of the myxoma virus and use of the living attenuated virus as an immunizing agent for myxomatosis. J. Infect. Dis. 114, 417–428.PubMedCrossRefGoogle Scholar
  32. 32.
    Huebner, R. J., Lane, W. T., Welch, A. D., Calabresi, P., McCollum, R. W., and Prusoff, W. H., 1963: Inhibition by 5-iododeoxyuridine of the oncogenic effects of adenovirus type 12 in hamsters. Science 142, 488–490.PubMedCrossRefGoogle Scholar
  33. 33.
    Fischer, D. S., Black, F. L., and Welch, A. D., 1965: Inhibition by nucleoside analogues of tumour formation by polyoma virus. Nature 206, 839–840.PubMedCrossRefGoogle Scholar
  34. 34.
    Graham, J. B., and Graham, R. M., 1962: Autogenous vaccine in cancer patients. Surg. Gyn. Obst. 114, 1–4.PubMedGoogle Scholar
  35. 35.
    Doniach, I., Crookston, J. H., and Cope, T. I., 1958: Attempted treatment of a patient with choriocarcinoma by immunization with her husband’s cells. J. Obst. Gyn. (Brit. Comm.) 65, 553–556.CrossRefGoogle Scholar
  36. 36.
    Hackett, E., and Beech, M., 1961: Immunological treatment of a case of choriocarcinoma. Brit. Med. J. 2, 1123–1126.CrossRefGoogle Scholar
  37. 37.
    Cinader, B., Hayley, M. A., Rider, W. D., and Warwick, O. H., 1961: Immunotherapy of a patient with choriocarcinoma. Canad. Med. Assoc. J. 84, 306–309.PubMedGoogle Scholar
  38. 38.
    Goldner, H., Girardi, A. J., and Hilleman, M. R., 1963: Attempts to interrupt virus tumorigenesis by immunization using homologous “Bjorklund-type” antigen. Proc. Soc. Exp. Biol. and Med. 114, 456–467.Google Scholar
  39. 39.
    Goldner, H., Girardi, A. J., Larson, V. M., and Hilleman, M. R., 1964: Interruption of SV40 virus tumorigenesis using irradiated homologous tumor antigen. Proc. Soc. Exp. Biol. and Med. 117, 851–857.Google Scholar
  40. 40.
    Goldner, H., Girardi, A. J., and Hilleman, M. R., 1965: Enhancement of virus tumorigenesis in hamsters attending vaccination procedures. Virology 27, 225–227.PubMedCrossRefGoogle Scholar
  41. 41.
    Girardi, A. J., 1965: Prevention of SV40 virus oncogenesis in hamsters, I. Tumor resistance induced by human cells transformed by SV40. Proc. Nat. Acad. Sci. 54, 445 – 451.PubMedCrossRefGoogle Scholar
  42. 42.
    Woodruff, M. F. A., 1964: Immunological aspects of cancer. Lancet 2, 265–270.PubMedCrossRefGoogle Scholar
  43. 43.
    Mathe, G., Amiel, J. L., Schwarzenberg, L., Cattan, A., and Schneider, M., 1965: Adoptive immunotherapy of acute leukemia: Experimental and clinical results. Symposium: Conference on Obstacles to the Control of Acute Leukemia, Warrenton, Va., March 21–23, 1965. Cancer Res. 25, 1525–1531.Google Scholar
  44. 44.
    Waksman, B. H., 1962: Auto-immunization and the lesions of auto-immunity. Medicine 41, 93–141.PubMedCrossRefGoogle Scholar
  45. 45.
    Brooke, M. S., 1965: Conversion of immunological paralysis to immunity by endotoxin. Nature 206, 63 5–636.Google Scholar
  46. 46.
    Sparck, J. V., and Volkert, M., 1965: Effect of adoptive immunity on experimentally induced leukaemia in mice. Nature 206, 578–579.PubMedCrossRefGoogle Scholar
  47. 47.
    Defendí, V., and Roosa, R. A., 1965: Effect of thymectomy on induction of tumors and on the transplantability of polyoma-induced tumors. Cancer Res. 25, 300–306.PubMedGoogle Scholar
  48. 48.
    Ting, R. C., and Law, L. W., 1965: The role of thymus in transplantation resistance induced by polyoma virus. J. Nat. Cancer Inst. 34, 521–527.PubMedGoogle Scholar
  49. 49.
    Kirschstein, R. L., Rabson, A. S., and Peters, E. A., 1964: Oncogenic activity of adenovirus 12 in thymectomized BALB/3 and C3H/HeN mice. Proc. Soc. Exp. Biol. and Med. 117, 198–200.Google Scholar
  50. 50.
    Sherman, J. D., Adner, M. M., and Dameshek, W., 1964: Direct injection of the thymus with antigenic substances. Proc. Soc. Exp. Biol. and Med. 115, 866–870.Google Scholar
  51. 51.
    Wagner, R. R., 1965: Interferon. A review and analysis of recent observations. Amer. J. Med. 38, 726–737.PubMedCrossRefGoogle Scholar
  52. 52.
    Ho, M., 1964: Identification and “induction” of interferon. Bact. Rev. 28, 367–381.PubMedGoogle Scholar
  53. 53.
    Hilleman, M. R., 1963: Interferon in prospect and perspective. J. Cellular Comp. Physiol. 62, 337–353.CrossRefGoogle Scholar
  54. 54.
    Hilleman, M. R., 1965: Immunologic, chemotherapeutic and interferon approaches to control of viral disease. Amer. J. Med. 38, 751–766.PubMedCrossRefGoogle Scholar
  55. 55.
    Lampson, G. P., Tytell, A. A., Nemes, M. M., and Hilleman, M. R., 1963: Purification and characterization of chick embryo interferon. Proc. Soc. Exp. Biol. and Med. 112, 468–478.Google Scholar
  56. 56.
    Friedman, R. M., and Rabson, A. S., 1964: Possible role of interferon in determining the oncogenic effect of polyoma virus variants. J. Exp. Med. 119, 71–81.PubMedCrossRefGoogle Scholar
  57. 57.
    Todaro, G. J., and Baron, S., 1965: The role of interferon in the inhibition of SV40 transformation of mouse cell line 3T3. Proc. Nat. Acad. Sci., U.S. 54, 752–756. CrossRefGoogle Scholar

Copyright information

© Springer-Verlag New York Inc. 1966

Authors and Affiliations

  • M. R. Hilleman
    • 1
  1. 1.Division of Virus and Cell Biology ResearchMerck Institute for Therapeutic ResearchWest PointUSA

Personalised recommendations