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The discovery that oncogenic viruses produce transformations in vitro was first made using cell populations recently derived from disaggregated tissues. Such cell populations have the properties characteristic of cell strains as defined by Hayflick; they have relatively short culture life-times, rather low plating efficiency, and are not completely homogenous. They can be cloned only with difficulty and quantitative studies of transformation frequency are not easy to perform.
KeywordsCell Generation Transformation Frequency Virus Infected Cell Rous Sarcoma Virus Host Cell Genome
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