Malignant Conversion by Avian Sarcoma Virus

  • Howard M. Temin
Part of the Recent Results in Cancer Research / Fortschritte der Krebsforschung / Progrès dans les recherches sur le cancer book series (RECENTCANCER, volume 6)


Basic cancer research involves two major questions: how cancer cells arise and how they differ in behavior from normal cells. Study of the interaction of the Rous sarcoma virus and related avian tumor viruses with sensitive chicken and duck cells in cell culture has suggested tentative answers to these questions. It appears that, in this system, cancer cells arise by the addition of genes to the normal cell and that these new genes, when expressed, cause changes in the cell so that the cancer cells require less than normal cells of a protein present in serum which controls cell multiplication. Therefore, under conditions in which this protein is limiting, the cancer cells have a selective advantage over normal cells.


Hyaluronic Acid Proper Condition Rous Sarcoma Virus Chicken Embryo Fibroblast United States Public Health 
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Copyright information

© Springer-Verlag New York Inc. 1966

Authors and Affiliations

  • Howard M. Temin
    • 1
  1. 1.McArdle LaboratoryUniversity of WisconsinMadisonUSA

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