The Response of Metanephric Rudiments to Polyoma Virus in Vitro Discussion
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Dr. Dawe’s observations on the response of organ cultures of mouse submandibular rudiments to polyoma virus (PV) can be summarized as follows: (a) the basic unit of the neoplastic response is the epithelio-mesenchymal complex, (b) neoplasms fail to appear from the isolated epithelial or mesenchymal components of the salivary-gland rudiments and (c) acquisition of neoplastic properties by salivary-gland epithelium requires “helper cells” which are provided for by salivary capsular mesenchyme but not by odontogenic mesenchyme. Furthermore, the responsiveness to PV oncogenesis was not maintained by exposure of “chimeric” dental epithelium and salivary-gland mesenchyme.
KeywordsOrgan Culture Polyoma Virus Metanephric Mesenchyme Mesenchymal Component Filter Assembly
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