The Response of Metanephric Rudiments to Polyoma Virus in Vitro Discussion

  • W. H. Kirsten
  • T. P. Weis
Part of the Recent Results in Cancer Research / Fortschritte der Krebsforschung / Progrès dans les recherches sur le cancer book series (RECENTCANCER, volume 6)


Dr. Dawe’s observations on the response of organ cultures of mouse submandibular rudiments to polyoma virus (PV) can be summarized as follows: (a) the basic unit of the neoplastic response is the epithelio-mesenchymal complex, (b) neoplasms fail to appear from the isolated epithelial or mesenchymal components of the salivary-gland rudiments and (c) acquisition of neoplastic properties by salivary-gland epithelium requires “helper cells” which are provided for by salivary capsular mesenchyme but not by odontogenic mesenchyme. Furthermore, the responsiveness to PV oncogenesis was not maintained by exposure of “chimeric” dental epithelium and salivary-gland mesenchyme.


Organ Culture Polyoma Virus Metanephric Mesenchyme Mesenchymal Component Filter Assembly 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Dawe, C. J.: Cell Sensitivity and Specificity of Response to Polyoma Virus. Natl. Cancer Inst. Monogr. 4, 67–128 (1960).PubMedGoogle Scholar
  2. 2.
    Flocks, J. S., Weis, T. P., Kleinman, D. C., and Kirsten, W. H.: Dose-Response Studies to Polyoma Virus in Rats. J. Nat. Cancer Inst. 35, 2 59–284 (1965).Google Scholar
  3. 3.
    Grobstein, C.: Inductive Interaction in the Development of the Mouse Metanephros. J. Exp. Zool. 130, 319–340 (1955).CrossRefGoogle Scholar
  4. 4.
    Grobstein, C.: Trans-Filter Induction of Tubules in Mouse Metanephrogenic Mesenchyme. Exp. Cell Res. 10, 424–440 (1956).PubMedCrossRefGoogle Scholar
  5. 5.
    Grobstein, C.: Some Transmission Characteristics of the Tubule-Inducing Influence of Mouse Metanephric Mesenchyme. Exp. Cell Res. 13, 575–587 (1957).PubMedCrossRefGoogle Scholar
  6. 6.
    Grobstein, C., and Parker, G.: Epithelial Tubule Formation by Mouse Metanephrogenic Mesenchyme Transplanted in Vivo. J. Natl. Cancer Inst. 20, 107–119 (1958).PubMedGoogle Scholar
  7. 7.
    SaxÉn, L., Vainio, T., and Toivonen, S.: Effect of Polyoma Virus on Mouse Kidney Rudiment in Vitro. J. Natl. Cancer Inst. 29, 597–631 (1962).PubMedGoogle Scholar
  8. 8.
    Vainio, T., SaxÉn, L., and Toivonen, S.: Acquisition of Cellular Resistance to Polyoma Virus During Embryonic Differentiation. Virology 20, 380–385 (1963).PubMedCrossRefGoogle Scholar
  9. 9.
    Weis, T. P., and Kirsten, W. H.: Interactions of Polyoma Virus and Organ Cultures of Embryonic Mouse Metanephric Rudiments. Arch. Path. 74, 3 80–386 (1962).Google Scholar

Copyright information

© Springer-Verlag New York Inc. 1966

Authors and Affiliations

  • W. H. Kirsten
    • 1
  • T. P. Weis
    • 1
  1. 1.Department of Pathology, Division of Biological SciencesThe University of ChicagoChicagoUSA

Personalised recommendations