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Development of PVA Hydrogels with Superior Lubricity for Artificial Cartilage

  • Atsushi SuzukiEmail author
  • Saori Sasaki
  • Teruo Murakami
Chapter
Part of the Soft and Biological Matter book series (SOBIMA)

Abstract

Physically cross-linked poly(vinyl alcohol) (PVA) gels are versatile biomaterials with their excellent biocompatibility and mechanical strength. Since the late 1970s, the semicrystalline PVA gels prepared by a freeze-thawing method (FT gel) have been extensively studied in characterizing the structural and functional properties for practical applications, such as artificial hydrogel cartilage. Recently, a simple preparation method for a physically cross-linked PVA gel by a cast-drying method (CD gel) was reported. Although the network nanostructures are similar, CD gels are transparent and elastic, while FT gels are opaque and less elastic. The crystallization conditions of these systems have been investigated; the gels become highly swollen and rigid by the selection of optimum preparation conditions. In this chapter, the mechanical properties of FT and CD gels, such as tearing energy, sliding friction, and abrasion loss, are reviewed in connection with the nano- and microstructures of physical PVA gels. The tribological properties of FT and CD gels are compared with that of natural cartilage. Based on experimental results, simple preparation methods to improve the mechanical and lubrication properties of physically cross-linked PVA gels are presented, and the mechanism of superior lubricity in newly developed PVA gels for artificial hydrogel cartilage is discussed.

Keywords

Poly(vinyl alcohol) gel Hybrid gel Superior lubricity Artificial hydrogel cartilage 

Notes

Acknowledgement

The author would like to thank Kuraray Co., Ltd. for supplying PVA powders. This work was supported by the Grant-in-Aid for Specially Promoted Research of Japan Society for the Promotion of Science (Kaken: 23000011).

References

  1. 1.
    Dowson D and Jin ZM. Micro-elastohydrodynamic Lubrication of Synovial Joints. Eng. Med., 1986; 15:65–67.CrossRefGoogle Scholar
  2. 2.
    Murakami, T. JSME International Journal, Series III 1990, 33, 465–474.Google Scholar
  3. 3.
    Murakami T, Higaki H, Sawae Y, Ohtsuki N, Moriyama S, Nakanishi Y. Proc. Inst. Mech. Eng. Pt. H J. Eng. Med. 1998, 212, 23–35.Google Scholar
  4. 4.
    Oka M, Ushio K, Kumar P, Ikeuchi K, Hyon SH, Nakamura T, Fujita H. Proc. IMechE Part H: J. Eng. Med. 2000, 214, 59–68.Google Scholar
  5. 5.
    Arakaki K, Kitamura N, Fujiki H, Kurokawa T, Iwamoto M, Ueno M, Kanaya F, Osada Y, Gong JP, Yasuda K. J. Biomed. Mat. Res. Part A 2010, 93, 1160–1168.Google Scholar
  6. 6.
    Cha W-I, Hyon S-H, Oka M, Ikada Y. Macromol. Symp. 1996, 109, 115–126.Google Scholar
  7. 7.
    Kobayashi M, Hyon S.H. Materials 2010, 3, 2753–2771.CrossRefGoogle Scholar
  8. 8.
    Nakashima K, Sawae Y, Murakami T. Tribo. Intern. 2007, 40, 1423–1427.CrossRefGoogle Scholar
  9. 9.
    Yarimitsu S, Nakashima K, Sawae Y, Murakami T. Tribology Online 2007, 2, 114–119.CrossRefGoogle Scholar
  10. 10.
    Bodugoz-Senturk H, Choi J, Oral E, Kung JH, Macias CE, Braithwaite G, Muratoglu OK. The effect of polyethylene glycol on the stability of pores in polyvinyl alcohol hydrogels during annealing. Biomaterials, 2008; 29: 141–149.CrossRefGoogle Scholar
  11. 11.
    Bodugoz-Senturk H, Macias CE, Kung JH, Muratoglu OK. Poly(vinyl alcohol)–acrylamide hydrogels as load-bearing cartilage substitute. Biomaterials 2009; 30: 589–596.CrossRefGoogle Scholar
  12. 12.
    Peppas NA. Turbidimetric studies of aqueous poly(vinyl alcohol) solutions. Makromolekulare Chemie 1975; 176: 3443–3440.CrossRefGoogle Scholar
  13. 13.
    Nambu M. Japanese Patent Kokai 1982; No. 57/130543. Nambu M. Rubber-like poly(vinyl alcohol) gel. Kobunshi Ronbunshu 1990; 47: 695–703 (in Japanese).Google Scholar
  14. 14.
    Murakami T, Sawae Y, Higaki H, Ohtsuki N, Moriyamaa S. The Adaptive Multimode Lubrication in Knee Prostheses with Artificial Cartilage during Walking. In: Dowson D et al. (eds) Elastohydrodynamics ‘96: Fundamentals and applications in lubrication and traction. Elsevier Science 1997, 383–394.Google Scholar
  15. 15.
    Otsuka E and Suzuki A. A Simple Method to Obtain a Swollen PVA Gel Crosslinked by Hydrogen Bonds. J. Appl. Polym. Sci. 2009, 114, 10–16.CrossRefGoogle Scholar
  16. 16.
    Otsuka E and Suzuki A. Swelling properties of physically cross-linked PVA gels prepared by a castdrying method. Prog. Colloid Polym. Sci. 2009, 136, 121–126.Google Scholar
  17. 17.
    Otsuka E, Sasaki S, Koizumi K, Hirashima Y, Suzuki A. Elution of polymers from physically cross-linked poly(vinyl alcohol) gels. Soft Matter 2010; 6: 6155–6159.CrossRefGoogle Scholar
  18. 18.
    Sasaki S and Suzuki A. Effects of repeated water exchange and the molecular-weight distribution of PVA cast gels on the elution of polymers. React Func Polym 2013; 73: 878–884.CrossRefGoogle Scholar
  19. 19.
    Suzuki A, Sasaki S, Sasaki S, Noh T, Nakashima K, Yarimitsu S, Murakami, T. Elution and Wear of PVA Hydrogels by Reciprocating Friction. Extended Abstract for World Tribology Congress 2013, 2013; Torino, in USB.Google Scholar
  20. 20.
    Murakami T, Sakai N, Yamaguchi T, Yarimitsua S, Nakashima K, Sawae Y, Suzuki A. Evaluation of a superior lubrication mechanism with biphasic hydrogels for artificial cartilage. Tribology International 2015; 89: 19–26.CrossRefGoogle Scholar
  21. 21.
    Sasaki S, Otsuka E, Hirashima Y, and Suzuki A. Elution of Polymers from PVA Cast Gels with Different Degrees of Polymerization and Hydrolysis. J. Appl. Polym. Sci. 2012, 126, E233–E241.CrossRefGoogle Scholar
  22. 22.
    Hassan CM and Peppas NA. Structure and applications of poly(vinyl alcohol) hydrogels produced by conventional crosslinking or by freezing/thawing methods. Adv Polym Sci 2000; 153: 37–65.CrossRefGoogle Scholar
  23. 23.
    Stauffer SR and Peppas NA. Poly(vinyl alcohol) hydrogels prepared by freezing-thawing cyclic processing, Polymer, 33 (1992) 3932–3936.CrossRefGoogle Scholar
  24. 24.
    Peppas NA and Stauffer SR. Reinforced uncrosslinked poly (vinyl alcohol) gels produced by cyclic freezing-thawing processes: a short review, J. Controlled Release, 16 (1991) 305–310.CrossRefGoogle Scholar
  25. 25.
    Lozinsky VI. A Brief History of Polymeric Cryogels. Adv Polym Sci 2014; 263: 1–48.CrossRefGoogle Scholar
  26. 26.
    Otsuka E, Komiya S, Sasaki S, Xing J, Bando Y, Hirashima Y, Sugiyama M, Suzuki A. Soft Matter 2012, 8, 8129–8136.CrossRefGoogle Scholar
  27. 27.
    Sasaki S and Suzuki A. Suzuki, Change in molecular weight distribution by elution of polymers from PVA cast gel. Polym. Bull. 2014, 71, 2383–2394.CrossRefGoogle Scholar
  28. 28.
    Sasaki S and Suzuki A. Polym. Adv. Tech. 2016, 27, 318–324.Google Scholar
  29. 29.
    Noh T, Bando Y, Ota K, Sasaki S, Suzuki A. Tear force of physically crosslinked poly(vinyl alcohol) gels with different submicrometer-scale network structures. J Appl Polym Sci 2015; 136: 121–126.Google Scholar
  30. 30.
    Suzuki A and Yoshikawa M. Water flow in poly(N-isopropylacrylamide) gels. J. Chem. Phys. 2006; 125: 174901.CrossRefGoogle Scholar
  31. 31.
    Suzuki A. Phase transition in gels of sub-millimeter size induced by interaction with stimuli. Adv Polym Sci, 1993; 110: 199–240.CrossRefGoogle Scholar
  32. 32.
    Sasaki S and Suzuki A. Effects of repeated water exchange and the molecular-weight distribution of PVA cast gels on the elution of polymers. React Func Polym 2013; 73: 878–884.CrossRefGoogle Scholar
  33. 33.
    Otsuka, E, Sugiyama, M, Suzuki, A. Network Microstructure of PVA Cast Gels Observed by SAXS Measurements. J. Phys.: Conf. Ser. 2010, 247, 012043.Google Scholar
  34. 34.
    Costa, H. S., Rocha, M. F., Andrade, G. I., Barbosa-Stancioli, E. F., Pereira, M. M., Orefice, R. L., Vasconcelos, W. L. and Mansur, H. S. Sol–gel derived composite from bioactive glass–polyvinyl alcohol. J. Mater. Sci. 2008;43, 494–502 (2008).Google Scholar
  35. 35.
    Peppas NA and Merrill EW. Crosslinked poly(vinyl alcohol) hydrogels as swollen elastic networks. J Appl Polym Sci 1977; 21: 1763–1770.CrossRefGoogle Scholar
  36. 36.
    Suzuki A and Sasaki S. Swelling and mechanical properties of physically crosslinked poly(vinyl alcohol) hydrogels. Proc IMechE Part H: Journal of Engineering in Medicine, 2015, 229, 828–844Google Scholar
  37. 37.
    Murakami T, Yarimitsu S, Nakashima K, Sawae Y, Sakai N, Araki T, Suzuki A. Time-dependent frictional behaviors in hydrogel artificial cartilage materials. Proc. 6th International Biotribology Forum, 2011, 65–68.Google Scholar
  38. 38.
    Murakami T, Importance of adaptive multimode lubrication mechanism in natural and artificial joints, Proc IMechE, J. Eng. Tribol., 2012; 226, 2012, 827–837.Google Scholar
  39. 39.
    Murakami T, Yarimitsu S, Nakashima K, Yamaguchi T, Sawae Y, Sakai N, Suzuki A. Superior Lubricity in Articular Cartilage and Artificial Hydrogel Cartilage. Proc IMechE Part J: J Engineering Tribology, 2014; 228, 1099–1111.CrossRefGoogle Scholar
  40. 40.
    Yamaguchi T, Murakami T. Surface friction and bulk transport properties in hydrogels. Preprint JAST Conference (in Japanese) 2013-9; 199–200.Google Scholar
  41. 41.
    Sakai N, Hagihara Y, Furusawa T, Hosoda N, Sawae Y, Murakami T. Analysis of biphasic lubrication of articular cartilage loaded by cylindrical indenter. Tribol Int 2012; 45: 225–36.CrossRefGoogle Scholar
  42. 42.
    Murakami T, Yarimitsu S, Nakashima K, Sakai N,Yamaguchi T, Sawae Y, Suzuki A. Synergistic Lubricating Function with Different Modes for Artificial Hydrogel Cartilage, Proc. The 8th International Biotribology Forum and The 36th Biotribology Symposium, 2015, 1–2.Google Scholar

Copyright information

© Springer Japan 2017

Authors and Affiliations

  1. 1.Department of Materials Science & Research Institute of Environment and Information SciencesYokohama National UniversityHodogaya-kuJapan
  2. 2.Research Center for Advanced BiomechanicsKyushu UniversityNishi-kuJapan

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