Aluminium(III) Speciation and Biological Effects

Implications In Human and Experimental Toxicity
  • P. Zatta
  • P. Zambenedetti
Part of the NATO ASI Series book series (ASEN2, volume 26)


Aluminium [Al(III)] is the third most abundant element as well as the most abundant metal-ion on the Earth’s crust. Apparently, Al(III) has no useful biological functions. However, few papers, as well as preliminary data from our laboratory, seem to indicate a possible role of Al(III) in the growing of animals and cell cultures [1]. The first toxicological studies on Al(III) were reported by Siems and Doellken respectively in 1886 and 1887 [2, 3]. A revival of interest on aluminium biology raised when Alfrey and coll. [4, 5] proved a connection between aluminium and certain pathologies, such as microcytic anemia, osteomalacia and dementia dialitica, related to the dialysis treatment of uremic patients. Furthermore, a possible connection between aluminium, as an aethiological factor and Alzheimer’s disease (AD) was first hypothesised by McLachlan and coll., in the early ’70s [6] but the issue is far to be fully demonstrated and it is still matter of discussion and investigation [7].


Metal Speciation Microcytic Anemia Aluminum Intoxication Murine Neuroblastoma Cell Aluminium Lactate 
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  1. 1.
    Carlisle, E.M. and Curran, M.J. (1993) Aluminum: an essential element for the chick, in M. Anke, D. Meissner and C.F. Mills (eds.) TEMA-8, Trace Elements in Man and Animals, Verlag Media Touristik, Gersdorf, Germany, pp. 695–698.Google Scholar
  2. 2.
    Siems, (1896) Inaug. Dorpat.Google Scholar
  3. 3.
    Doellken, V. (1897) Uber die Wirkung del aluminium mit besonderer berucksichtigung der durch des aluminium verersaucher lesionen in zentralnerven system, Naunyn-Schmiedebergs Arch. Exp. Palhol Pahrmakol. 40, 98–120.CrossRefGoogle Scholar
  4. 4.
    Alfrey, A.C., Le Gendre, G.R. and Kaehny, W.D. (1976) The dialysis encephalopathy syndrome. Possible aluminum intoxication, N. Engl. J. Med., 294, 184–188.CrossRefGoogle Scholar
  5. 5.
    Alfrey, A.C. (1994) Aluminum intoxication in renal failure. A historic overview, in M. Nicolini, P.F. Zatta and B. Corain (guest eds.), Life Chem. Rep. (special issue) 11, 197–205.Google Scholar
  6. 6.
    Crapper, D.R., Krishnan, S.S. and Dalton, A.J. (1973) Brain aluminum distribution in Alzheimer’s disease and experimental neurofibrillary degeneration, Science 180, 511–513CrossRefGoogle Scholar
  7. 7.
    Zatta, P.F. (1993) Controversial aspects of aluminum(III) accumulation and subcompartmentation in Alzheimer’s disease, Trace Elem. Med., 10, 120–128.Google Scholar
  8. 8.
    Candy, J.M., Oakley, A.E., McArthur, F.K., Taylor, G.A., Mountfort, S.A. and Edwardson, J.A. (1994) Microanalytical and molecular approaches to the syudy of aluminium in relation to Alzheimer’s disease, in M. Nicolini, P.F. Zatta and B. Corain (guest eds.), Life Chem. Rep. (special issue) 11, 55–69.Google Scholar
  9. 9.
    Zatta, P.F., Nicolini, M., and Corain, B. (1991) Aluminum(III) toxicity and blood-brain barrier permeability, in M. Nicolini, P.F. Zatta and B. Corain (eds.), Aluminum in Chemistry, Biology and Medicine, Raven Press, New York and Cortina Intern., Verona, pp. 73–82.Google Scholar
  10. 10.
    Martin, R.B. (1991) Aluminum in biological systems, in M. Nicolini, P.F. Zatta and B. Corain (eds.), Aluminum in Chemistry, Biology and Medicine, Cortina Intern., Verona and Raven Press, New York, pp. 3–20.Google Scholar
  11. 11.
    Zatta, P., Perazzolo, M. and Corain, B. (1989) Tris acetylacetonate aluminum(III) induces osmotic fragility and acanthocytes formation in suspended erythrocytes, Toxicol. Lett., 45, 15–21.CrossRefGoogle Scholar
  12. 12.
    Zatta, P., Zambenedetti, P., Pizziuti, A. and Perazzolo, M. (1995) Different effects of aluminum upon carbonic anhydrases and Na+/K+-ATPase activities in rat, Neurose. Lett., 197, 65–68.CrossRefGoogle Scholar
  13. 13.
    Zambenedetti, P., Tisato, F., Corain, B., and Zatta, P. (1994) Reactivity of Al(III) with membrane phospholipids: a NMR approach, Biometals, 7, 244–252.CrossRefGoogle Scholar
  14. 14.
    Zatta, P., Zambenedetti, P. and Filippi B. (1996) Opposite effects of Al(III) upon mammalian and yeast hexokinase activities, (sumitted)Google Scholar
  15. 15.
    Zatta, P. and Zambenedetti, P. (1996) Aluminum speciation and morphological differentiation in murine neuroblastoma cells, Biol. Trace Elem. Res. 51, 77–85.CrossRefGoogle Scholar
  16. 16.
    Johnson, G.V.W. and Jope, R.S. (1987) Aluminum alters AMP and cyclic GMP levels but not presynaptic cholinergic markers in rat brain in vivo, Brain Res., 403, 1–6.CrossRefGoogle Scholar
  17. 17.
    Northrup, J.K., Smigel, M.D., Sterweiss, P.C. and Gilman, A.G. (1987) The subunits stimulatory regulatory component of adenylate cyclase, J. Biol. Chem., 258, 11369–11376.Google Scholar
  18. 18.
    Zatta, P., Bordin, C. and Favarato, M. (1993) The inhibition of trypsin and α-chymotrypsin proteolytic activity by aluminum (III), Arch. Biochem. Biophys. 303, 407–411.CrossRefGoogle Scholar
  19. 19.
    Zatta, P., Zambenedetti, P., Bruna, V. and Filippi, B. (1994) Activation of acetylcholinesterase by aluminium(III): the relevance of the metal speciation, NeuroReport, 5, 1777–1780.CrossRefGoogle Scholar
  20. 20.
    Zatta, P., Zambenedetti, P. and Cagnolini, C. (1996) Effects of Al(III) speciation upon the Krebs cycle enzymes and the glutamate dehydrogenase activities (submitted)Google Scholar
  21. 21.
    Favarato, M., Zatta, P., Perazzolo, M., Fontana, L. and Nicolini, M. (1992) Aluminum(III) influences the permeability of the blood-brain barrier to[14C]sucrose in rats, Brain Res., 569, 330–335.CrossRefGoogle Scholar
  22. 22.
    Mirzabekov, T., Ballarin, C., Nicolini, M., Zatta, P. and Sorgato, C. (1993) Reconstitution of the native mitochondrial outer membrane in planar bilayer. Comparison with outer membrane in a patch pipette and effect of aluminum compounds, J. Membr. Biol. 133, 129–143.Google Scholar
  23. 23.
    Bragadin, M., Dell’Antone, P. and Zatta, P. (1994) Inhibitory effect of aluminium on H+− ATPase in isolated lysosomes, in M. Nicolini, P.F. Zatta and B. Corain (guest eds.), Life Chem. Rep. (special issue) 11, 165–169.Google Scholar
  24. 24.
    Zatta, P., Zambenedetti, P. and Masiero, S. (1994) Effects of aluminum lactate on murine neuroblastoma cells, NeuroToxicology, 15, 789–798.Google Scholar
  25. 25.
    Zatta, P., Perazzolo, M., Bombi, G.G., Corain, B. and Nicolini, M. (1989) The role of speciation of aluminum(III) on the stability of cell membranes and on the activity of selected enzymes, in K. Iqbal, Wisniewski, H.M. and B. Winblas, Alzheimzer’s Disease and Related Disorders, A. Liss, Inc., New York, pp. 1087–1094.Google Scholar

Copyright information

© Springer Science+Business Media Dordrecht 1997

Authors and Affiliations

  • P. Zatta
    • 1
  • P. Zambenedetti
    • 1
  1. 1.CNR-Center on Metalloproteins at the Department of BiologyUniversity of PadovaPadovaItaly

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