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Aluminium(III) Speciation and Biological Effects

Implications In Human and Experimental Toxicity
  • P. Zatta
  • P. Zambenedetti
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  • 259 Downloads
Part of the NATO ASI Series book series (ASEN2, volume 26)

Abstract

Aluminium [Al(III)] is the third most abundant element as well as the most abundant metal-ion on the Earth’s crust. Apparently, Al(III) has no useful biological functions. However, few papers, as well as preliminary data from our laboratory, seem to indicate a possible role of Al(III) in the growing of animals and cell cultures [1]. The first toxicological studies on Al(III) were reported by Siems and Doellken respectively in 1886 and 1887 [2, 3]. A revival of interest on aluminium biology raised when Alfrey and coll. [4, 5] proved a connection between aluminium and certain pathologies, such as microcytic anemia, osteomalacia and dementia dialitica, related to the dialysis treatment of uremic patients. Furthermore, a possible connection between aluminium, as an aethiological factor and Alzheimer’s disease (AD) was first hypothesised by McLachlan and coll., in the early ’70s [6] but the issue is far to be fully demonstrated and it is still matter of discussion and investigation [7].

Keywords

Metal Speciation Microcytic Anemia Aluminum Intoxication Murine Neuroblastoma Cell Aluminium Lactate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media Dordrecht 1997

Authors and Affiliations

  • P. Zatta
    • 1
  • P. Zambenedetti
    • 1
  1. 1.CNR-Center on Metalloproteins at the Department of BiologyUniversity of PadovaPadovaItaly

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