From the Mass Production of Methylococcus Capsulatus to the Efficient Separation and Isolation of Methane Monooxygenase Proteins. Characterization of Novel Intermediates in Substrate Reactions of Methane Monooxygenase

  • Katherine E. Liu
  • Ann M. Valentine
  • Danli Wang
  • Boi H. Huynh
  • Dale E. Edmondson
  • Athanasios Salifoglou
  • Stephen J. Lippard
Part of the NATO ASI Series book series (ASEN2, volume 26)


Methanotrophs are naturally occurring bacteria which utilize methane as their sole source of metabolic energy and carbon.* Due to their ability to catalyze the formation of methanol from methane under ambient conditions, interest has developed over their use as alternative methanol producers.2 In addition, the fact that they oxidize a variety of hydrocarbon substrates other than methane, attracted a lot of attention in their potential exploitation in bioremediation.3 The metalloenzyme system responsible for the conversion of methane to methanol (Reaction 1) in the initial step of their metabolism is methane monooxygenase (MMO).


Iron Atom Intermediate Species Iron Center Methane Monooxygenase Methylococcus Capsulatus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media Dordrecht 1997

Authors and Affiliations

  • Katherine E. Liu
    • 1
  • Ann M. Valentine
    • 1
  • Danli Wang
    • 2
  • Boi H. Huynh
    • 2
  • Dale E. Edmondson
    • 3
  • Athanasios Salifoglou
    • 1
  • Stephen J. Lippard
    • 1
  1. 1.Department of ChemistryMassachusetts Institute of TechnologyCambridgeUSA
  2. 2.the Department of PhysicsEmory UniversityAtlantaUSA
  3. 3.the Department of BiochemistryEmory UniversityAtlantaUSA

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