Modeling Manganese Redox Enzymes

  • Dimitris P. Kessissoglou
Part of the NATO ASI Series book series (ASEN2, volume 26)


Manganese is an essential element in many biological processes. Two functional values can be distinguished; the MnII as a Lewis acid, like divalent ions, Magnesium, Calcium, Zinc and in higher oxidation states(MnIII, MnIV) as an oxidation catalyst, like Copper, Iron, Cobalt. Manganese redox enzymes1 with manganese in oxidation states 2+, 3+ and 4+ are: a manganese-containing ribonucleotide reductase 2, 3, 15 isolated from B. ammoniagemes; Mn ThiosulfateOxidase 4 containing a binuclear MnII site; Manganese SOD 5, 6 catalyzing the dismutasion of Superoxide radicals to oxygen and hydrogen peroxide with a single MnIII center; The Manganese Peroxidase(MnP) 7–10 is one of the two known enzymes capable for the oxidative degradation of lignin containing protoporphyrin IX heme prosthetic group; non heme manganese catalase 11–19 containing two manganese per subunit and the Oxygen Evolving Complex 20–40, catalyzing one of the most important reactions occurring in the plants, the light driven oxidation of water to oxygen and protons, containing four manganese atoms while the presence of calcium and chloride ions is required for proper functioning. In this report we will describe how modeling chemistry provides insight into the structure, chemical properties and reactivity of some manganese redox enzymes.


Ribonucleotide Reductase Mixed Valence Manganese Atom Trinuclear Complex ORTEP Diagram 
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Copyright information

© Springer Science+Business Media Dordrecht 1997

Authors and Affiliations

  • Dimitris P. Kessissoglou
    • 1
  1. 1.Department of General and Inorganic ChemistryAristotle University of ThessalonikiThessalonikiGreece

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