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Li+ Transport Properties in Perfused Neuronal Cells by 7Li NMR Spectroscopy

  • M. M. C. A. Castro
  • J. Nikolakopoulos
  • C. Zachariah
  • D. M. de Freitas
  • C. F. G. C. Geraldes
  • R. Ramasamy
Chapter
  • 251 Downloads
Part of the NATO ASI Series book series (ASEN2, volume 26)

Abstract

Lithium salts have been clinically used, for more than forty years, in the treatment of manic-depression or bipolar disease, as well as in other psychiatric and non-psychiatric disorders, such as depression, schizophrenia, hyperthyroidism, conditions caused by the Herpes simplex and AIDS virus and low blood cells counts associated with chemotherapy [1, 2]. In spite of the well recognized therapeutic effectiveness of lithium, the mechanism of action at the molecular and cellular level of the active species – the lithium ion, Li+ – is still unclear.

Keywords

Neuroblastoma Cell Human Neuroblastoma Cell Line Shift Reagent Leak Pathway Microcarrier Bead 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media Dordrecht 1997

Authors and Affiliations

  • M. M. C. A. Castro
    • 1
  • J. Nikolakopoulos
    • 2
  • C. Zachariah
    • 2
  • D. M. de Freitas
    • 2
  • C. F. G. C. Geraldes
    • 1
  • R. Ramasamy
    • 3
  1. 1.Biochemistry DepartmentUniversity of CoimbraCoimbraPortugal
  2. 2.Chemistry DepartmentLoyola University of ChicagoChicagoUSA
  3. 3.Department of Cardiovascular MedicineUC DavisUSA

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