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Pathways in the Chromium(VI)-Mediated Formation of DNA Lesions: A Review

  • A. Kortenkamp
  • M. Casadevall
  • P. Da Cruz Fresco
  • R. O. J. Shayer
Chapter
Part of the NATO ASI Series book series (ASEN2, volume 26)

Abstract

The advent of mutation assays, the development of sensitive methods for the analysis of DNA damage, and the application of spectroscopic methods to biomedical problems have greatly aided our understanding of the mechanisms by which chromium(VI) compounds exert their carcinogenicity. It is now well established that chromium(VI) compounds are strong mutagens, causing point mutations, chromosome aberrations and sister-chromatid exchanges in microorganisms, cultured mammalian cells and laboratory animals [1]. A number of DNA lesions including single strand breaks, alkali-labile sites, DNA-protein cross links, DNA- interstrand cross links [2–11], and recently DNA-amino acid cross links [12] have been observed after treatment of cultured mammalian cells with chromium(VI). The finding that chromium(VI) itself is unreactive towards DNA [13, 14] has prompted research into the reductive conversion of chromium(VI), ultimately to chromium(III), as a crucial step in the formation of DNA lesions.

Keywords

Strand Break Cross Link Single Strand Break Abasic Site Interstrand Cross Link 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media Dordrecht 1997

Authors and Affiliations

  • A. Kortenkamp
    • 1
  • M. Casadevall
    • 2
  • P. Da Cruz Fresco
    • 3
  • R. O. J. Shayer
    • 1
  1. 1.Department of ToxicologyThe School of Pharmacy, University of LondonLondonUK
  2. 2.Gorlaeus LaboratoriesLeiden Institute of ChemistryLeidenThe Netherlands
  3. 3.Laboratorio de Farmacologia, Facultade de FarmaciaUniversidade do PortoPortoPortugal

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