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Tin-Based Antitumor Drugs

  • M. Gielen
Chapter
Part of the NATO ASI Series book series (ASEN2, volume 26)

Abstract

An overview is given of the results of the in vitro screening against MCF-7, a mammary tumor, and WiDr, a colon carcinoma, of several series of organotin compounds: diorganotin pyridinedicarboxylates, bis(salicylato)tetraorgano-distannoxanes, diorganotin and triorganotin benzoates.

Many di-and triorganotin compounds exhibit very promising in vitro antitumor activities: di-n-butyltin 2, 6-difluorobenzoate and triphenyltin salicylates are characterized by ID50 values comparable to that of mitomycin C.

Keywords

Antitumor Activity Mammary Tumor Colon Carcinoma Antitumor Drug Organotin Compound 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media Dordrecht 1997

Authors and Affiliations

  • M. Gielen
    • 1
  1. 1.Faculty of Applied Sciences, Department of General and Organic ChemistryFree University of Brussels V.U.B.BrusselBelgium

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