Synthesis, Spectroscopy and Structures of Complexes of PD(II) with 4N-Substituted Derivatives of 2-Acetylpyridine Thiosemicarbazone

  • Dimitra Kovala-Demertzi
  • Asimina Domopoulou
  • Mavroudis A. Demertzis
Part of the NATO ASI Series book series (ASEN2, volume 26)


The reactions of 2-acetylpyridine thiosemicarbazone (HAc4DH), 4N-phenyl-2- acetylpyridine thiosemicarbazone (HAc4Ph), and 4N-dimethyl-2-acetyl pyridine thiosemicarbazone (HAc4DM) with palladium(II) were studied. The ligands and the palladium(II) complexes have been characterized by spectroscopic, structural and electrochemical techniques. Their effect on DNA synthesis of P388 and LI210 cell cultures is also reported.


Palladium complexes 4N-substituted thiosemicarbazones antitumour activity 


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© Springer Science+Business Media Dordrecht 1997

Authors and Affiliations

  • Dimitra Kovala-Demertzi
    • 1
  • Asimina Domopoulou
    • 1
  • Mavroudis A. Demertzis
    • 1
  1. 1.Inorganic Chemistry, Department of ChemistryUniversity of IoanninaIoanninaGreece

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