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The Mechanisms of Metal Carcinogenicity

Chromium(VI)-induced Genotoxicity: Direct and Indirect Pathways
  • Diane M. Stearns
  • Karen E. Wetterhahn
Chapter
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Part of the NATO ASI Series book series (ASEN2, volume 26)

Abstract

Metal carcinogens may act through both genotoxic and non-genotoxic pathways. Chromium(VI) (Cr(VI)) is an example of a genotoxic metal carcinogen. People can be exposed to Cr(VI) in the environment, from chromium-contaminated lands, and workers can be exposed in occupations that produce, refine, or use Cr(VI), for example in the manufacture of stainless steel, paints and pigments; and in chrome plating, leather tanning, and wood preserving industries. Toxic effects of acute exposure to Cr(VI) include perforation of the nasal septum, ulcerations of the skin, and contact dermatitis. Exposure of human populations to chronic high levels of Cr(VI) has been correlated with an increased incidence of lung cancer [1].

Keywords

Electron Paramagnetic Resonance Strand Break Electron Paramagnetic Resonance Signal Electron Paramagnetic Resonance Spectroscopy Strand Breakage 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media Dordrecht 1997

Authors and Affiliations

  • Diane M. Stearns
    • 1
  • Karen E. Wetterhahn
    • 1
  1. 1.Department of ChemistryDartmouth CollegeHanoverUSA

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