Effects of Calcium, Magnesium, Zinc, and Iron on Nickel Carcinogenesis: Inhibition Versus Enhancement

  • K. S. Kasprzak
Part of the NATO ASI Series book series (ASEN2, volume 26)


This paper reviews the investigations on interactions between nickel and calcium, magnesium, zinc, or iron, aimed at elucidation of the mechanisms of nickel carcinogenesis and its prevention. Depending on the animal species, target tissues, particular metal compounds, and routes of administration, the divalent metals magnesium, calcium, or zinc, inhibit or have no effect on nickel carcinogenesis, whereas trivalent iron can either inhibit or enhance it. The molecular mechanisms involved in the observed effects are likely to include interactions at the tissue and cellular metal transport levels. They may, as well, depend on binding competition among metal ions at chromatin (e.g., DNA, histones, transcription factors, DNA repair enzymes) and other regulatory molecules in both the target cells, which give rise to tumors, and immune cells, which are responsible for controlling tumor growth.


Renal Tumor Nickel Compound Nickel Toxicity Nickel Sulphide Local Sarcoma 
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Copyright information

© Springer Science+Business Media Dordrecht 1997

Authors and Affiliations

  • K. S. Kasprzak
    • 1
  1. 1.Laboratory of Comparative CarcinogenesisNational Cancer Institute, FCRDCFrederickUSA

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