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Modeling the Metal Binding Sites in Core Histones: Interactions of Carcinogenic Ni(II) with the -CAIH- Motif of Histone H3

  • W. Bal
  • K. S. Kasprzak
Chapter
Part of the NATO ASI Series book series (ASEN2, volume 26)

Abstract

This paper presents results of studies on interactions of carcinogenic nickel with -CAIH-, a potential metal binding motif in nuclear chromatin. Structural and mechanistic results are discussed in the perspective of various concepts in nickel carcinogenesis. Evidence is presented for a major role of oxidative mechanism of damage caused by Ni(II) binding and reactivity on both genotoxic (DNA) and epigenetic (core histones) levels. Preliminary results of a study of (H3-H4)2 histone tetramer supporting the validity of CAIH model are also shown.

Keywords

Ternary Complex Isosbestic Point Linker Histone Chicken Erythrocyte Histone Sequence 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media Dordrecht 1997

Authors and Affiliations

  • W. Bal
    • 1
    • 2
  • K. S. Kasprzak
    • 1
  1. 1.Laboratory of Comparative CarcinogenesisNational Cancer Institute, FCRDCFrederickUSA
  2. 2.Faculty of ChemistryUniversity of WroclawWroclawPoland

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