Perinatal Effects of Metals and Cancer in Offspring

  • M. A. Sipowicz
  • B. A. Diwan
  • D. Ramljak
  • G. S. Buzard
  • W. Yu
  • M. P. Waalkes
  • J. M. Rice
  • K. S. Kasprzak
  • L. M. Anderson
Part of the NATO ASI Series book series (ASEN2, volume 26)


Human exposure to metals, environmentally or occupationally, continues to increase in many areas [1]. Such exposures of both men and women may adversely affect their reproductive capability, and impact on fertility and on pregnancy outcomes. Recent reviews are available, covering studies of effects on fertility, spontaneous abortions, premature delivery, low birth weight, and teratogenesis in humans [2, 3], and developmental toxicity in laboratory animals [4]. An even more insidious concern is the possibility of causation of persistent subtle deleterious effects in the offspring, as a result of preconception, transplacental, or neonatal exposure. Neurological effects have been documented, especially for transplacental and neonatal exposure to lead [5] and methylmercury [6]. In addition, over the last several years, evidence has been accumulating from both epidemiological and experimental investigations that perinatal exposure to metals may result in a later increase in risk for cancer. This evidence is reviewed here.


Luteinizing Hormone Leydig Cell Umbilical Cord Blood Childhood Cancer Nickel Acetate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media Dordrecht 1997

Authors and Affiliations

  • M. A. Sipowicz
    • 1
  • B. A. Diwan
    • 1
    • 2
  • D. Ramljak
    • 1
  • G. S. Buzard
    • 1
  • W. Yu
    • 1
  • M. P. Waalkes
    • 1
  • J. M. Rice
    • 1
  • K. S. Kasprzak
    • 1
  • L. M. Anderson
    • 1
  1. 1.Laboratory of Comparative Carcinogenesis, Division of Basic SciencesNational Cancer InstituteUSA
  2. 2.Intramural Research Support Program, SAIC FrederickFrederick Cancer Research and Development CenterFrederickUSA

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