History of Drug Reaction in Children Suffering from Cancer

  • Bisma Zafar
  • Maliha GhaffarEmail author
  • Hina Salahuddin


The purpose of this study is to provide the researchers with the bigger academic network for the understanding of the incorporated proof about current pharmacogenomics information on pediatric oncology and hematology. This primary assessment will help and guide the researchers and clinicians by giving a thought about the current situation of research, as far as customizing drug for kids with malignant growth (cancer). This study also describes the gene-drug associations with substantial and adequate power of association put forward by PharmGKB (Pharmacogenomics Knowledgebase). Some drugs with strong pharmacogenetic evidence like thiopurines and some with moderate pharmacogenetic evidence like vincristine are also discussed. Upcoming suggestions to achieve this objective will help to put forward the recommendations. Pharmacogenetic gene-drug link studies, thus, influence the reconsidering of study plans to produce sensible results. Genetic roots of oxidative force reaction or genome stability disturbing reaction were categorized as association with moderate evidence but have not yet been tested in children.


Pediatrics Pharmacogenomics PharmGKB Thiopurine Irinotecan Cisplatin Methotrexate Cyclophosphamide and vincristine 


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© Springer Nature Singapore Pte Ltd. 2020

Authors and Affiliations

  1. 1.Department of BiotechnologyUniversity of OkaraOkaraPakistan
  2. 2.Department of ZoologyUniversity of OkaraOkaraPakistan

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