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Pharmacogenomics of Cisplatin-Induced Toxicity in Children

  • Aadil Rasheed
  • Maliha Ghaffar
  • Hina SalahuddinEmail author
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Abstract

Cisplatin is a widely used chemotherapeutics agent used to treat cancers in all age groups. It induces apoptosis but is deactivated by some proteins that results in adverse side effects. It has been found to produce toxicity in children. Though it has a high cure rate, still the toxicity caused by cisplatin cannot be neglected. Cisplatin-induced ototoxicity and nephrotoxicity are major consequences of its side effects. It produces GST polymorphisms, megalin SNPs, thiopurine S-methyltransferase, and catechol-O-methyltransferase variants. An elevated ROS level is evident in all affected by cisplatin-induced ototoxicity. Similarly, different SNPs related to nephrotoxicity have also been reported. Comprehensive studies of other cisplatin-induced toxicity are yet to be carried out.

Keywords

Cisplatin Pediatrics Pharmacogenomics Children Toxicity Chemotherapeutics Cancer Side effects 

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Copyright information

© Springer Nature Singapore Pte Ltd. 2020

Authors and Affiliations

  • Aadil Rasheed
    • 1
  • Maliha Ghaffar
    • 1
  • Hina Salahuddin
    • 1
    Email author
  1. 1.Department of ZoologyUniversity of OkaraOkaraPakistan

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