Adapting the Foreign Soil: Factors Promoting Tumor Metastasis

  • Ramish RiazEmail author
  • Shah Rukh Abbas
  • Maria Shabbir


Majority of the deaths associated with cancer are attributed to metastasis. Till now there had been no cure of metastasis. Metastatic cells are usually resistant to conventional radiotherapy and chemotherapeutic agents. Metastasis can occur even after decades of treatment of primary tumor. Insights into the molecular mechanisms promoting metastasis could help in developing novel techniques that will prevent development of metastasis. The chapter discusses the major molecular mechanisms that support metastasis. It highlights the mechanisms involved in metastatic dormancy, immunomodulation, and mechano-transduction and their possible role in establishment of metastasis. It gives in-depth review of tumor microenvironment and how microenvironment plays role in supporting micrometastasis. It also discusses the mechanisms and factors which help the micrometastasis to escape the immune response and develop overt metastasis.


Metastasis Tumor microenvironment Immune modulation Mechano-transduction Chemotherapeutic agents 


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Copyright information

© Springer Nature Singapore Pte Ltd. 2020

Authors and Affiliations

  1. 1.Atta Ur Rahman School of Applied Biosciences, NUSTIslamabadPakistan
  2. 2.Pakistan Institute of Medical SciencesIslamabadPakistan
  3. 3.Department of Industrial BiotechnologyAtta Ur Rahman School of Applied Biosciences, NUSTIslamabadPakistan
  4. 4.Department of Healthcare BiotechnologyAtta Ur Rahman School of Applied Biosciences, NUSTIslamabadPakistan

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