Therapeutic Implication of Cancer Stem Cells

  • Sudeep BoseEmail author
  • Sartaj Khurana
  • Shrey Ashley Philip


Most of the conventional cancer treatments have limited selectivity, are temporarily effective, and have adverse side effects. The potential of cancer stem cell (CSC)-based therapies has recently attracted much attention to override the detrimental impact of conventional therapies. Here we have highlighted potential strategies including identification of cancer stem cell biomarkers, interfering with circuitry network associated with drug resistance, sensitization of CSC to chemotherapy, and radiation therapy through protein targeting. CSCs display differential metabolic activity, specific signaling pathway activity in tumor initiation, metastasis, and drug resistance. Thus identification of CSC-specific markers distinct from the total cancer cell population is essential. Given the fact that the stem cell is one of the key components of organogenesis and maintenance of homeostasis throughout life, improvement of treatment modalities based on CSC therapies holds wish for better overall survival and better quality of life of cancer sufferers, specifically for patients with metastatic disorder. Therefore, in this book chapter, we have mainly discussed aberrant regulation of gene expression and some signaling pathways in CSCs and implication of CSC surface markers for designing new therapies for better clinical outcome.


Cancer stem cells Biomarkers Therapeutics Stemness CSC signaling Targets 


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Copyright information

© Springer Nature Singapore Pte Ltd. 2020

Authors and Affiliations

  • Sudeep Bose
    • 1
    • 2
    Email author
  • Sartaj Khurana
    • 1
    • 2
  • Shrey Ashley Philip
    • 1
  1. 1.Amity Institute of BiotechnologyAmity University Uttar-PradeshNoidaIndia
  2. 2.Amity Institute of Molecular Medicine and Stem Cell ResearchAmity University Uttar PradeshNoidaIndia

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