Transarterial Therapies for Benign and Malignant Liver Tumors

  • Suyash S. Kulkarni
  • Nitin Sudhakar Shetty
  • Shashank Mishra
  • David Narayan


The liver is the site for both benign lesions as well as primary and secondary malignancies. While surgery is generally avoided in benign neoplasm, a considerable proportion of patients are not eligible for curative surgical treatment despite advancement in surveillance and treatment options due to advanced tumor stage or poor hepatic functional reserve. The use of transarterial catheter-directed therapies in such patients has gained acceptance as a useful option to treat both benign and malignant liver tumors. Transarterial therapies involve treatment of tumors by injecting various agents into the hepatic artery which include bland embolization, transarterial chemoembolization, or radioembolization depending on the clinical presentation, type of tumor, and stage of the disease. While bland embolization essentially devascularizes the tumor, chemoembolization controls tumors by combining both chemotherapeutic effects of the antineoplastic drug along with ischemic necrosis due to arterial embolization. Radioembolization, on the other hand, acts on the tumor through radiation that is emitted by radiopharmaceutical beads injected into the tumor through the hepatic artery. In this chapter, the basic principles, techniques, complications, and follow-up assessments of various transarterial therapies for malignant and benign liver tumors are reviewed and clinical applicability briefed.


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Copyright information

© Springer Nature Singapore Pte Ltd. 2021

Authors and Affiliations

  • Suyash S. Kulkarni
    • 1
  • Nitin Sudhakar Shetty
    • 1
  • Shashank Mishra
    • 1
  • David Narayan
    • 1
  1. 1.Department of Interventional RadiologyTata Memorial Centre, Homi Bhabha National InstituteMumbaiIndia

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