Interventions for Portal Hypertension: Hepatic Vein Pressure Gradient and Trans Jugular Liver Biopsy
- 39 Downloads
Hepatic vein pressure gradient (HVPG) measurement for the quantification of portal hypertension is considered the gold standard for the measurement of portal pressure. It is defined as the difference in pressures between the occluded and free hepatic vein. The pressure in the occluded hepatic vein represents the hepatic sinusoidal pressure, which is slightly lower than the portal pressure. This difference in pressure is however clinically insignificant. Measurement of the HPVG is used to quantify the degree of portal hypertension in chronic liver disease. Normal HPVG values are between 1 to 5 mmHg. Higher pressures are considered to represent portal hypertension. Pressures greater than 10 mmHg represent clinically significant hypertension, while pressures above 12 mmHg increase the risk of variceal rupture [1, 2].
- 4.Reiberger T, Ulbrich G, Ferlitsch A, et al. Carvedilol for primary prophylaxis of variceal bleeding in cirrhotic patients with hemodynamic non-response to propranolol. Hepatology. 2012;56(S1):272A–3A.Google Scholar
- 20.Atar E, Ben Ari Z, Bachar GN, Amlinski Y, Neyman C, Knizhnik M, et al. A comparison of transjugular and plugged-percutaneous liver biopsy in patients with contraindications to ordinary percutaneous liver biopsy and an “in-house” protocol for selecting the procedure of choice. Cardiovasc Intervent Radiol. 2010 Jun;33(3):560–4.CrossRefGoogle Scholar