Crohn’s Disease (CD)
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Crohn’s disease is a chronic inflammatory disorder which can affect the entire gastrointestinal (GI) tract. It is a global disease with the highest prevalence in Europe and North America (>0.3%). The incidence is stable or decreasing in western countries and increasing in newly industrialized countries (Ng et al. 2017). Crohn’s disease is most commonly located in the terminal ileum and the proximal colon but may involve any part of the GI tract. The inflammations generally appear in outlined sections, affect all laminae of the intestinal wall, and cause abscesses and fistulae. Many patients also experience extraintestinal manifestations (Levine and Burakoff 2011). Key symptoms of Crohn’s disease are persistent diarrhea, abdominal pain, fever, weight loss, and rectal bleeding (Gomollon et al. 2017). The course of the disease can be described with recurrent relapses and symptom-free intervals, both of which varying in length and strength. A barrier defect, impaired and inappropriate...
References and Further Reading
- Boye, B., Lundin, K. E., Jantschek, G., et al. (2011). INSPIRE study: Does stress management improve the course of inflammatory bowel disease and disease-specific quality of life in distressed patients with ulcerative colitis or Crohn’s disease? A randomized controlled trial. Inflammatory Bowel Diseases, 17, 1863–1873.CrossRefGoogle Scholar
- Gracie, D. J., Irvine, A. J., Sood, R., et al. (2017). Effect of psychological therapy on disease activity, psychological comorbidity, and quality of life in inflammatory bowel disease: A systematic review and meta-analysis. The Lancet Gastroenterology & Hepatology, 2, 189–199.CrossRefGoogle Scholar
- Levine, J. S., & Burakoff, R. (2011). Extraintestinal manifestations of inflammatory bowel disease. Gastroenterology & Hepatology, 7, 235–241.Google Scholar